Professor Nick Anstey

Senior principal research fellow

Qualifications:

PhD, University of Western Australia, 2001; Fellowship of the Royal Australasian College of Physicians, 1992; Master of Science, University of London, 1989; Diploma of Tropical Medicine and Hygiene, London, 1989; Bachelor of Medicine and Bachelor of Surgery (Hons), University of Western Australia, 1985.

Approved level of HDR supervision at Charles Darwin University:

Principal Supervisor for PhD

Location:

Darwin - Royal Darwin Hospital campus

Biography:

Professor Nicholas Anstey is an infectious diseases physician at the Menzies School of Health Research in Darwin.

He collaborates with clinical and epidemiological research programs in Indonesia and Malaysia, and with malaria networks in the Asia-Pacific and Africa.

The goal of his translational research program is the reduction in morbidity and mortality from malaria. His research spans the epidemiology, pathophysiology, treatment and prevention of uncomplicated and severe malaria from the three major species causing malaria deaths in our region: Plasmodium falciparum, P. vivax and P knowlesi.

Nick is the recipient of the inaugural Gustav Nossal Medal in Global Health from the Australian Academy of Science and an Honorary International Fellow of the American Society of Tropical Medicine and Hygiene.  

Through ongoing collaborations with national and international networks he aims to continue to link basic, clinical and field research to develop new preventative and treatment strategies for malaria.

Professor Nick Anstey
Email
Research Themes
Pathogenesis
  1. Kho S, Qotrunnada L, Leonardo L, Andries B, […], Buffet P, Anstey N.M. (2021). Hidden Biomass of Intact Malaria Parasites in the Human Spleen. New England J Medicine; 384(21):2067-2069. doi:10.1056/NEJMc2023884.
  2. Kho S, Qotrunnada L, Leonardo L, Andries B, […], Buffet P, Anstey N.M. (2021). Evaluation of splenic accumulation and colocalization of immature reticulocytes and Plasmodium vivax in asymptomatic malaria: A prospective human splenectomy study. PLoS Medicine; 18(5):e1003632. doi: 10.1371/journal.pmed.1003632.
  3. Barber BE, Grigg M, Piera K, Chen Y, William T, Weinberg J, Yeo T, Anstey NM. (2021). Endothelial glycocalyx degradation and disease severity in Plasmodium vivax and Plasmodium knowlesi malaria. Sci Rep;11(1):9741. doi: 10.1038/s41598-021-88962-6.
  4. Woodford J, Gillman A, Jenvey P, Roberts J, […], Anstey NM, McCarthy JS (2021). Positron emission tomography and magnetic resonance imaging in experimental human malaria to identify organ-specific changes in morphology and glucose metabolism: A prospective cohort study. PLoS Medicine; 18(5):e1003567. doi:10.1371/journal.pmed.1003567.
  5. Yeo, T.W., Weinberg, J.B., Lampah, D.A., Kenangalem, E., Bush, P., [...], Anstey, N.M. (2019). Glycocalyx Breakdown is Associated with Severe Disease and Fatal Outcome in Plasmodium falciparum Malaria. Clinical Infectious Diseases, 69(10): 1712–1720. doi:10.1093/cid/ciz038.
  6. Barber, B.E., Grigg, M.J., Piera, K., Amante, F.H., William, T., [...], Anstey, N.M. (2019). Anti-phosphatidylserine IgM and IgG antibodies are higher in vivax than falciparum malaria, and associated with early anemia in both species. The Journal of Infectious Diseases, 220(9):1435–1443. doi:10.1093/infdis/jiz334.
  7. Kho, S., Barber, B.E., Johar, E., Andries, B., Poespoprodjo, J.R., [...], Anstey, N.M*., McMorran, B*. [*equal contribution] (2018). Platelets kill circulating parasites of all major Plasmodium species in human malaria. Blood, 132(12):1332-1344. doi:10.1182/blood-2018-05-849307.
  8. Barber, B.E., Grigg, M.J., Piera, K.A., William, T., Cooper, D.J., [...], Anstey, N.M. (2018). Intravascular haemolysis in severe Plasmodium knowlesi malaria: association with endothelial activation, microvascular dysfunction, and acute kidney injury. Emerging Microbes Infection, 7(1):106. doi: 10.1038/s41426-018-0105-2.
  9. Barber, B.E., Russell, B., Grigg, M.J., Zhang, R., [...], Anstey, N.M*., Yeo, T.W*. [*equal contribution] (2018). Reduced red blood cell deformability in Plasmodium knowlesi malaria. Blood Advances, 2(4): 433-443.
Epidemiology, Surveillance and Strengthening Health Systems
  1. Currie BJ, Mayo M, Ward LM, Kaestli M, Meumann EM, […], Anstey, N.M. (2021). The Darwin Prospective Melioidosis Study: a 30-year prospective, observational investigation. Lancet Infectious Diseases, S1473-3099(21)00022-0. doi: 10.1016/S1473-3099(21)00022-0.
  2. Cooper, D.J., Rajahram, G.S., William, T., Jelip, J., Mohammad, R., [...], Anstey, N.M., Barber, B.E. (2020). Plasmodium knowlesi malaria in Sabah, Malaysia, 2015-2017: ongoing increase in incidence despite near-elimination of the human-only Plasmodium species. Clinical Infectious Diseases, 70(3): 361–367. doi:10.1093/cid/ciz237
  3. Kenangalem, E., Poespoprodjo, J.R., Douglas, N.M., Burdam, F.H., Gdeumana, K., [...], Anstey N.M., Price, R.N. (2019). Malaria morbidity and mortality following introduction of a universal policy of artemisinin-based treatment for malaria in Papua, Indonesia: a longitudinal surveillance study. PLoS Medicine 16(5): e1002815. doi: 10.1371/journal.pmed.1002815.
  4. Grigg, M.J., Cox, J., William, T., Jelip, J., Fornace, K.M., [...], Anstey, N.M., Yeo, T.W., Drakeley, C.J. (2017). Individual factors associated with the risk of acquiring human Plasmodium knowlesi malaria in Malaysia: a case-control study. Lancet Planet Health, 1(3), e97–e104. doi: 10.1016/S2542-5196(17)30031-1.
  5. Grigg, M.J., William, T., Piera, K.A., Rajahram, G.S., Jelip, J., [...], Anstey, N.M. (2017). Plasmodium falciparum artemisinin resistance monitoring in Sabah, Malaysia: in vivo therapeutic efficacy and kelch13 molecular marker surveillance. Malaria Journal, 17(1):463. doi: 10.1186/s12936-018-2593-x.
Clinical trials, meta-analyses and systematic reviews
  1. Mousa A, Al-Taiar A, Anstey NM, […], Okell LC (2020). The impact of delayed treatment of uncomplicated P. falciparum malaria on progression to severe malaria: A systematic review and a pooled multicentre individual-patient meta-analysis. PLoS Medicine - doi.org/10.1371/journal.pmed.1003359
  2. Rajahram, G.S., Cooper, D.J., William, T., Grigg, M.J., Anstey, N.M. and Barber, B.E. (2019). Deaths from Plasmodium knowlesi malaria: case series and systematic review. Clinical Infectious Diseases. 69(10):1703–1711. doi:10.1093/cid/ciz011.
  3. Commons, R.J., Simpson, J.A., Thriemer, K., Abreha, T., Adam, I., Anstey, N.M., [...], Price, R.N. (2019). The efficacy of dihydroartemisinin-piperaquine and artemether-lumefantrine with and without primaquine on Plasmodium vivax recurrence: a systematic review and individual patient data meta-analysis. PLoS Medicine, 16(10): e1002928. doi: 10.1371/journal.pmed.1002928. 
  4. Grigg, M.J., William, T., Barber, B.E., Rajahram, G.S., Menon, J., [...], Anstey, N.M. (2018). Artemether-lumefantrine versus chloroquine for the treatment of uncomplicated Plasmodium knowlesi malaria: an open-label randomized controlled trial (CAN KNOW). Clinical Infectious Diseases, 66(2): 229-236. doi: 10.1093/cid/cix779.
  5. Commons RJ, Simpson JA, Thriemer K, Humphreys GS, Abreha T, Alemu SG, Añez A, Anstey NM, […], Price, R.N. (2018). The effect of chloroquine dose and primaquine on Plasmodium vivax recurrence: a WorldWide Antimalarial Resistance Network systematic review and individual patient pooled meta-analysis. Lancet Infectious Diseases, 18(9): 1025-1034. doi: 10.1016/S1473-3099(18)30348-7. 
  6. Douglas, N.M., Poespoprodjo, J.R., Patriani, D., Malloy, M.J., Kenangalem, E., [...], Anstey N.M., Price, R.N. (2017). Unsupervised primaquine for the treatment of Plasmodium vivax malaria relapses in southern Papua: a hospital-based cohort study. PLoS Medicine, 14(8): e1002379. doi: 10.1371/journal.pmed.1002379. 

Clinical spectrum
  1. Anstey, N.M., Grigg, M.J., Rajahram, G.S., […], Kho, S, Barber, B.E (2021). Knowlesi malaria: human risk factors, clinical spectrum, and pathophysiology. Advances Parasitology, 113 in press
  2. Kho, S., Andries, B., Poespoprodjo, J.R., Commons, R.J., Shanti, P.A.I., [...], Anstey, N.M., Price, R.N. (2019). High risk of Plasmodium vivax malaria following splenectomy in Papua, Indonesia. Clinical Infectious Diseases, 68(1):51-60. doi: 10.1093/cid/ciy403.
  3. Grigg, M.J., William, T., Barber, B.E., Rajahram, G.S., Menon, J., [...], Anstey, N.M. (2018). Age-related clinical spectrum of Plasmodium knowlesi malaria and predictors of severity. Clinical Infectious Diseases 67(3):350-359. doi: 10.1093/cid/ciy065.
  4. Aung, N.M., Nyein, P.P., Htut, T.Y., Htet, Z.W., Kyi, T.T., Anstey, N.M., [...], Hanson, J. (2018). Antibiotic Therapy in Adults with Malaria: High Rate of Clinically Significant Bacteremia in Hospitalized Adults Diagnosed with Falciparum Malaria. The American Journal of Tropical Medicine and Hygiene, 99(3): 688–696. doi:10.4269/ajtmh.18-0378. 
Click here to view more Nick Anstey publications in PubMed.
  1. MEDIA RELEASE | Menzies researchers RESPOND to priority diseases in our global neighbourhood
  2. MEDIA RELEASE | Menzies researchers in the top 2 per cent
  3. Medical Express | Using paracetamol for protecting kidneys in patients with severe malaria
  4. Using paracetamol for protecting kidneys in patients with severe malaria
  5. Researchers at CDU some of the most influential in their fields
  6. Parasit malaria bersembunyi di organ limpa
  7. Parasit Malaria Bisa Bersembunyi di Limpa Manusia
  8. Penelitian Berhasil Ungkap Parasit Malaria Bersembunyi di Limpa Sumber: https://mediaindonesia.com/humaniora/408850/penelitian-berhasil-ungkap-parasit-malaria-bersembunyi-di-limpa
  9. Parasites may accumulate in spleens of asymptomatic individuals infected with malaria
  10. Malaria is not only a blood disease, it also hides in the spleen, scientists have discovered
  11. Hidden malaria life cycle discovered in the spleen
  12. CDU academics named among world’s most influential
  13. An open letter from 119 scientists and researchers to The Lancet
  14. How we can end TB by 2030
  15. CDU, Menzies researcher leads battle against malaria
  16. MediaNewsroomCDU, Menzies researcher leads battle against malaria CDU, Menzies researcher leads battle against malaria
  17. Asia–Pacific research partnerships set to tackle big challenges
  18. Research reveals defence against malaria parasites
  19. Xinhuanet.com|Platelets kill up to 60 pct of malaria parasites: Australian study
  20. Platelets the first line of defence in malaria patients
  21. New evidence supports radical treatment of widespread form of malaria
  22. Award no tall order for Matthew - Darwin Sun
  23. NT News | Brains Trust Born
  24. Monkey malaria researcher named NT Young Tall Poppy
  25. New Australian-led malaria research powerhouse gears up to hunt down malaria across the Asia-Pacific
  26. Territory Q features HOT NORTH
  27. Adult male farmers most at risk of contracting monkey malaria in Malaysia
  28. $2m grant to combat drug resistant malaria and tuberculosis
  29. TerritoryQ: War on Malaria, Prof Ric Price and Prof Nicholas Anstey
  30. Menzies leaders inducted into important new health and medical academy
  31. Infectious diseases specialist honoured with prestigious Academy Award
  32. Menzies secures critical funding for malaria and tropical health research