Professor Nick Anstey

Senior principal research fellow

Qualifications:

PhD, University of Western Australia, 2001; Fellowship of the Royal Australasian College of Physicians, 1992; Master of Science, University of London, 1989; Diploma of Tropical Medicine and Hygiene, London, 1989; Bachelor of Medicine and Bachelor of Surgery (Hons), University of Western Australia, 1985.

Approved level of HDR supervision at Charles Darwin University:

Principal Supervisor for PhD

Location:

Darwin - Royal Darwin Hospital campus

Biography:

Professor Nicholas Anstey is an infectious diseases physician at the Menzies School of Health Research in Darwin.

He collaborates with clinical and epidemiological research programs in Indonesia and Malaysia, and with malaria networks in the Asia-Pacific and Africa.

The goal of his translational research program is the reduction in morbidity and mortality from malaria. His research spans the epidemiology, pathophysiology, treatment and prevention of uncomplicated and severe malaria from the three major species causing malaria deaths in our region: Plasmodium falciparum, P. vivax and P knowlesi.

Nick is the recipient of the inaugural Gustav Nossal Medal in Global Health from the Australian Academy of Science and an Honorary International Fellow of the American Society of Tropical Medicine and Hygiene.  

Through ongoing collaborations with national and international networks he aims to continue to link basic, clinical and field research to develop new preventative and treatment strategies for malaria.

Epidemiology, Surveillance and Strengthening Health Systems
  1. Cooper, D.J., Rajahram, G.S., William, T., Jelip, J., Mohammad, R., [...], Anstey, N.M., Barber, B.E. (2020). Plasmodium knowlesi malaria in Sabah, Malaysia, 2015-2017: ongoing increase in incidence despite near-elimination of the human-only Plasmodium species. Clinical Infectious Diseases, 70(3): 361–367. doi:10.1093/cid/ciz237

  2. Kenangalem, E., Poespoprodjo, J.R., Douglas, N.M., Burdam, F.H., Gdeumana, K., [...], Anstey N.M., Price, R.N. (2019). Malaria morbidity and mortality following introduction of a universal policy of artemisinin-based treatment for malaria in Papua, Indonesia: a longitudinal surveillance study. PLoS Medicine 16(5): e1002815. doi: 10.1371/journal.pmed.1002815.

  3. Grigg, M.J., Cox, J., William, T., Jelip, J., Fornace, K.M., [...], Anstey, N.M., Yeo, T.W., Drakeley, C.J. (2017). Individual factors associated with the risk of acquiring human Plasmodium knowlesi malaria in Malaysia: a case-control study. Lancet Planet Health, 1(3), e97–e104. doi: 10.1016/S2542-5196(17)30031-1.

  4. Auburn, S., Benavente, E.D., Miotto, O., Pearson, R.D., Amato, R., [...], Anstey, N.M., Kwiatkowski, D.P., Price, R.N. (2018). Genomic analysis of a pre-elimination Malaysian Plasmodium vivax population reveals selective pressures and changing transmission dynamics. Nature Communications, 9(1): 2585. doi: 10.1038/s41467-018-04965-4

  5. Grigg, M.J., William, T., Piera, K.A., Rajahram, G.S., Jelip, J., [...], Anstey, N.M. (2017). Plasmodium falciparum artemisinin resistance monitoring in Sabah, Malaysia: in vivo therapeutic efficacy and kelch13 molecular marker surveillance. Malaria Journal, 17(1):463. doi: 10.1186/s12936-018-2593-x.

Clinical trials, meta-analyses and systematic reviews
  1. Rajahram, G.S., Cooper, D.J., William, T., Grigg, M.J., Anstey, N.M. and Barber, B.E. (2019). Deaths from Plasmodium knowlesi malaria: case series and systematic review. Clinical Infectious Diseases. 69(10):1703–1711. doi:10.1093/cid/ciz011.
  2. Commons, R.J., Simpson, J.A., Thriemer, K., Abreha, T., Adam, I., Anstey, N.M., [...], Price, R.N. (2019). The efficacy of dihydroartemisinin-piperaquine and artemether-lumefantrine with and without primaquine on Plasmodium vivax recurrence: a systematic review and individual patient data meta-analysis. PLoS Medicine, 16(10): e1002928. doi: 10.1371/journal.pmed.1002928
  3. Grigg, M.J., William, T., Barber, B.E., Rajahram, G.S., Menon, J., [...], Anstey, N.M. (2018). Artemether-lumefantrine versus chloroquine for the treatment of uncomplicated Plasmodium knowlesi malaria: an open-label randomized controlled trial (CAN KNOW). Clinical Infectious Diseases, 66(2): 229-236. doi: 10.1093/cid/cix779.
  4. Commons RJ, Simpson JA, Thriemer K, Humphreys GS, Abreha T, Alemu SG, Añez A, Anstey NM, […], Price, R.N. (2018). The effect of chloroquine dose and primaquine on Plasmodium vivax recurrence: a WorldWide Antimalarial Resistance Network systematic review and individual patient pooled meta-analysis. Lancet Infectious Diseases, 18(9): 1025-1034. doi: 10.1016/S1473-3099(18)30348-7
  5. Douglas, N.M., Poespoprodjo, J.R., Patriani, D., Malloy, M.J., Kenangalem, E., [...], Anstey N.M., Price, R.N. (2017). Unsupervised primaquine for the treatment of Plasmodium vivax malaria relapses in southern Papua: a hospital-based cohort study. PLoS Medicine, 14(8): e1002379. doi: 10.1371/journal.pmed.1002379
Pathogenesis
  1. Yeo, T.W., Weinberg, J.B., Lampah, D.A., Kenangalem, E., Bush, P., [...], Anstey, N.M. (2019). Glycocalyx Breakdown is Associated with Severe Disease and Fatal Outcome in Plasmodium falciparum Malaria. Clinical Infectious Diseases, 69(10): 1712–1720. doi:10.1093/cid/ciz038.
  2. Barber, B.E., Grigg, M.J., Piera, K., Amante, F.H., William, T., [...], Anstey, N.M. (2019). Anti-phosphatidylserine IgM and IgG antibodies are higher in vivax than falciparum malaria, and associated with early anemia in both species. The Journal of Infectious Diseases, 220(9):1435–1443. doi:10.1093/infdis/jiz334.
  3. Kho, S., Minigo, G., Andries, B., Leonardo, L., Prayoga, P., [...], Yeo, T.W. (2019). Circulating neutrophil extracellular traps and neutrophil activation are increased in proportion to disease severity in human malaria. The Journal of Infectious Diseases, 219(12):1994–2004. doi:10.1093/infdis/jiy661
  4. Kho, S., Barber, B.E., Johar, E., Andries, B., Poespoprodjo, J.R., Kenangalem, E., [...], McMorran, B. (2018). Platelets kill circulating parasites of all major Plasmodium species in human malaria. Blood, 132(12):1332-1344. doi:10.1182/blood-2018-05-849307.
  5. Oyong, D.A., Kenangalem, E., Poespoprodjo, J.R., Beeson, J.G., Anstey, N.M. [...], Boyle, M.J. (2018). Loss of complement regulatory proteins on uninfected erythrocytes in vivax and falciparum malaria anemia. JCI Insight, 3(22): 124854. doi: 10.1172/jci.insight.124854.
  6. Barber, B.E., Grigg, M.J., Piera, K.A., William, T., Cooper, D.J., [...], Anstey, N.M. (2018). Intravascular haemolysis in severe Plasmodium knowlesi malaria: association with endothelial activation, microvascular dysfunction, and acute kidney injury. Emerging Microbes Infection, 7(1):106. doi: 10.1038/s41426-018-0105-2.
  7. Barber, B.E., Russell, B., Grigg, M.J., Zhang, R., William, T., [...], Yeo, T.W. (2018). Reduced red blood cell deformability in Plasmodium knowlesi malaria. Blood Advances, 2(4): 433-443.
  8. Barber, B.E., Grigg, M.J., William, T., Piera, K.A., Boyle, M., Yeo, T.W., and Anstey, N.M. (2017). Effects of Aging on Parasite Biomass, Inflammation, Endothelial Activation, Microvascular Dysfunction and Disease Severity in Plasmodium knowlesi and Plasmodium falciparum Malaria. Journal Infectious Diseases, 215(12): 1908-1917. doi: 10.1093/infdis/jix193.

Clinical spectrum
  1. Kho, S., Andries, B., Poespoprodjo, J.R., Commons, R.J., Shanti, P.A.I., [...], Anstey, N.M., Price, R.N. (2019). High risk of Plasmodium vivax malaria following splenectomy in Papua, Indonesia. Clinical Infectious Diseases, 68(1):51-60. doi: 10.1093/cid/ciy403.
  2. Grigg, M.J., William, T., Barber, B.E., Rajahram, G.S., Menon, J., [...], Anstey, N.M. (2018). Age-related clinical spectrum of Plasmodium knowlesi malaria and predictors of severity. Clinical Infectious Diseases 67(3):350-359. doi: 10.1093/cid/ciy065.
  3. Aung, N.M., Nyein, P.P., Htut, T.Y., Htet, Z.W., Kyi, T.T., Anstey, N.M., [...], Hanson, J. (2018). Antibiotic Therapy in Adults with Malaria: High Rate of Clinically Significant Bacteremia in Hospitalized Adults Diagnosed with Falciparum Malaria. The American Journal of Tropical Medicine and Hygiene, 99(3): 688–696. doi:10.4269/ajtmh.18-0378
Click here to view more Nick Anstey publications in PubMed.
  1. How we can end TB by 2030

    How we can end TB by 2030

    Date

    A regional research collaboration with the Menzies School of Health Research has been highly productive in building capacity in PNG and Indonesia,.

  2. CDU, Menzies researcher leads battle against malaria

    CDU, Menzies researcher leads battle against malaria

    Date

    National Tribune Online news | Graduating this week with a PhD, rising star malaria researcher Dr Steven Kho.

  3. MediaNewsroomCDU, Menzies researcher leads battle against malaria CDU, Menzies researcher leads battle against malaria

    MediaNewsroomCDU, Menzies researcher leads battle against malaria CDU, Menzies researcher leads battle against malaria

    Date

    Blood platelets, neutrophils and the spleen have novel roles in people with malaria, according to new research from Charles Darwin University (CDU) and Menzies School of Health Research.

  4. Asia–Pacific research partnerships set to tackle big challenges

    Asia–Pacific research partnerships set to tackle big challenges

    Date

    The largest grant, of $257,767, goes to the Menzies School of Health Research for a project with collaborators in Bangladesh, Indonesia and the Netherlands.

  5. Research reveals defence against malaria parasites

    Research reveals defence against malaria parasites

    Date

    The study, which has just been published in the prestigious journal Blood, was led by Associate Professor Brendan McMorran at ANU and Professor Nick Anstey at Darwin's Menzies School of Health Research

  6. Xinhuanet.com|Platelets kill up to 60 pct of malaria parasites: Australian study

    Xinhuanet.com|Platelets kill up to 60 pct of malaria parasites: Australian study

    Date

    The study, published by the Menzies School of Health Research (MSHR) in Australia's Northern Territory (NT), revealed that platelets attack and kill malaria parasites in the bloodstream.

  7. Platelets the first line of defence in malaria patients

    Platelets the first line of defence in malaria patients

    Date

    The humble platelet is usually regarded as just a tiny cell that helps the blood clot. A study just published in the prestigious journal Blood has found that platelets attack and kill malaria parasites in infected humans to reduce the number of parasites circulating in their blood.

  8. New evidence supports radical treatment of  widespread form of malaria

    New evidence supports radical treatment of widespread form of malaria

    Date

    A team of malaria experts from a large international research collaboration has today published results supporting the need for a radical cure strategy to tackle one of the most debilitating forms of malaria caused by the Plasmodium vivax parasite.

  9. Award no tall order for Matthew - Darwin Sun

    Award no tall order for Matthew - Darwin Sun

    Date

    A DARWIN scientist has been named the Young Tall Poppy Scientist of the Year in recognition of his research into a type of monkey malaria transmitted to humans via mosquitoes.

  10. NT News | Brains Trust Born

    NT News | Brains Trust Born

    Date

    Researchers at Darwin's Menzies School of Health Research will play a key role in a new push to fight the scourge of malaria in the Asia-Pacific region.

  11. Monkey malaria researcher named NT Young Tall Poppy

    Monkey malaria researcher named NT Young Tall Poppy

    Date

    Menzies School of Health Research (Menzies) clinical research fellow Dr Matthew Grigg has been named the 2017 NT Young Tall Poppy Scientist of the Year in recognition for ongoing research into Plasmodium knowlesi (P. knowlesi) malaria, a type of monkey malaria transmitted to humans via mosquitos in Southeast Asia.

  12. New Australian-led malaria research powerhouse gears up to hunt down malaria across the Asia-Pacific

    New Australian-led malaria research powerhouse gears up to hunt down malaria across the Asia-Pacific

    Date

    Australia will take a leadership role in the Asia-Pacific region in a new initiative to help our nearest neighbours rid the scourge of malaria, in a new National Health and Medical Research Council (NHMRC) Centre for Research Excellence in Malaria Elimination.

  13. Territory Q features HOT NORTH

    Territory Q features HOT NORTH

    Date

    Read about our HOT NORTH collaboration in the latest Territory Q Magazine.

  14. Adult male farmers most at risk of contracting monkey malaria in Malaysia

    Adult male farmers most at risk of contracting monkey malaria in Malaysia

    Date

    Lead author, Menzies School of Health Research research fellow, Dr Matthew Grigg has specialised in identifying and researching risk factors and treatment for P. knowlesi malaria in Sabah, Malaysian Borneo.

  15. $2m grant to combat drug resistant malaria and tuberculosis

    $2m grant to combat drug resistant malaria and tuberculosis

    Date

    A $2m research grant to work towards the prevention, control and elimination of malaria and tuberculosis (TB) in Southeast Asia and the Pacific has been awarded to a consortium led by Menzies School of Health Research, in collaboration with Burnet Institute, the Department of Foreign Affairs and Trade announced today.

  16. TerritoryQ: War on Malaria, Prof Ric Price and Prof Nicholas Anstey

    TerritoryQ: War on Malaria, Prof Ric Price and Prof Nicholas Anstey

    Date

    A medical team based in Darwin has put itself at the centre of the goal to eliminate malaria from the Asia-Pacific

  17. Menzies leaders inducted into important new health and medical academy

    Menzies leaders inducted into important new health and medical academy

    Date

    Three Menzies researchers inducted as Fellows of the newly formed Australian Academy of Health and Medical Sciences.

  18. Infectious diseases specialist honoured with prestigious Academy Award

    Infectious diseases specialist honoured with prestigious Academy Award

    Date

    One of Australia’s leading infectious diseases specialists has been recognised with a prestigious national award for his contributions in tackling the global burden of malaria.

  19. Menzies secures critical funding for malaria and tropical health research

    Menzies secures critical funding for malaria and tropical health research

    Date

    The millions of people worldwide who suffer from malaria and other tropical infections each year will benefit from the awarding of a federal fellowship to one of the country's leading clinical researchers in tropical health.