Professor Nick Anstey

Senior principal research fellow

Qualifications:

PhD, University of Western Australia, 2001; Fellowship of the Royal Australasian College of Physicians, 1992; Master of Science, University of London, 1989; Diploma of Tropical Medicine and Hygiene, London, 1989; Bachelor of Medicine and Bachelor of Surgery (Hons), University of Western Australia, 1985.

Approved level of HDR supervision at Charles Darwin University:

Principal Supervisor for PhD

Location:

Darwin - Royal Darwin Hospital campus

Biography:

Professor Nicholas Anstey is an infectious diseases physician at the Menzies School of Health Research in Darwin.

He collaborates with clinical research programs in Sabah, Malaysia; Timika, Papua, Indonesia; and with malaria networks in the Asia-Pacific and Africa.

The goal of his translational research program is the reduction in morbidity and mortality from malaria and tuberculosis. A major clinical research focus is on the pathophysiology, immunology, treatment and prevention of uncomplicated and severe malaria from the three major species causing malaria deaths in our region: Plasmodium falciparum, P. vivax and P knowlesi.

Nick was announced as the recipient of the inaugural Gustav Nossal Medal from the Australian Academy of Science in November 2014. Nick was awarded the Medal for his contributions in tackling the global burden of malaria. (The Gustav Nossal Medal recognises research of the highest standing in the field of global health, and is awarded by Australia’s peak scientific body.)

Through ongoing collaborations with national and international networks he aims to continue to link basic, clinical and field research to develop new preventative and treatment strategies for malaria.

  1. Yeo, T.W., Lampah. D.A., Kenangalem, E., Tjitra, E., Weinberg, J.B., Granger, D.L., Price, R.N., & Anstey, N.M. (2014). Decreased Endothelial Nitric Oxide Bioavailability, Impaired Microvascular Function, and Increased Tissue Oxygen Consumption in Children with Falciparum Malaria. Journal of Infectious Diseases. In press.
  2. Yeo, T.W., Lampah, D.A., Kenangalem, E., Tjitra, E., Price, R.N., & Anstey, N.M. (2013). Impaired skeletal muscle microvascular function and increased skeletal muscle oxygen consumption in severe falciparum malaria. Journal of Infectious Diseases, 207(3), 528-536.
  3. William, T., Rahman, H.A., Jelip, J., Ibrahim, M.Y., Menon, J., Grigg, M., Yeo, T.W., Anstey, N.M, & Barber, B.E. (2013). Increasing incidence of Plasmodium knowlesi malaria following control of P. falciparum and P. vivax malaria in Sabah, Malaysia. PLoS Neglected Tropical Diseases, 7(1), e2026.
  4. Pinzon-Charry, A., Woodberry, T., Kienzle, V., McPhun, V., Minigo, G., Lampah, D.A., Kenangalem, E., Engwerda, C.R., López, J.A., Anstey, N.M., & Good, M.F. (2013). Apoptosis and dysfunction of blood dendritic cells in patients with falciparum and vivax malaria. Journal of Experimental Medicine; 210: 1635-46.
  5. Barber, B.E., William, T., Grigg, M.J., Menon, J., Auburn, S., Marfurt, J., Anstey, N.M., & Yeo, T.W. (2013). A prospective comparative study of knowlesi, falciparum, and vivax malaria in Sabah, Malaysia: High proportion with severe disease from Plasmodium knowlesi and Plasmodium vivax but no mortality with early referral and artesunate therapy. Clinical Infectious Diseases, 56(3), 383-397.
  6. Yeo, T.W., Lampah, D.A., Rooslamiati, I., Gitawati, R., Tjitra, E., Kenangalem, E., Price, R.N., Duffull, S.B., & Anstey, N.M. (2013). A randomized pilot study of L-arginine infusion in severe falciparum malaria: preliminary safety, efficacy and pharmacokinetics. PLOS one, 8(7), e69587.
  7. Woodberry, T., Minigo, G., Piera, K.A., Amante, F.H., Pinzon-Charry, A., Good, M.F., Lopez, J.A., Engwerda, C.R., McCarthy, J.S., & Anstey, N.M. (2012). Low-level plasmodium falciparum blood-stage infection causes dendritic cell apoptosis and dysfunction in healthy volunteers. Journal of Infectious Diseases, 206(3), 333-340.
  8. Yeo, T.W., Lampah, D.A., Tjitra, E., Gitawati, R., Darcy, C.J., Jones, C., Kenangalem, E., McNeil, Y.R., Granger, D.L., Lopansri, B.K., Weinberg, J.B., Price, R.N., Duffull, S.B., Celermajer, D.S., & Anstey, N.M. (2010). Increased asymmetric dimethylarginine in severe falciparum malaria: Association with impaired nitric oxide bioavailability and fatal outcome. PLoS Pathogens, 6(4), 1-8.
  9. Yeo, T.W., Lampah, D.A., Gitawat, R., Tjitra, E., Kenangalem, E., Piera, K., Price, R.N., Duffull, S.B., Celermajer, D.S., & Anstey, N.M. (2008). Angiopoietin-2 is associated with decreased endothelial nitric oxide and poor clinical outcome in severe falciparum malaria. Proceedings of the National Academy of Sciences of the United States of America, 105(44), 17097-17102.
  10. Yeo, T.W., Lampah, D.A., Gitawati, R., Tjitra, E., Kenangalem, E., McNeil, Y.R., Darcy, C.J., Granger, D.L., Weinberg, J.B., Lopansri, B.K., Price, R.N., Duffull, S.B., Celermajer, D.S., & Anstey, N.M. (2007). Impaired nitric oxide bioavailability and L-arginine-reversible endothelial dysfunction in adults with falciparum malaria. Journal of Experimental Medicine, 204(11), 2693-2704.
  11. South East Asian Quinine Artesunate Malaria Trial (SEAQUAMAT) group. (2005). Artesunate versus quinine for treatment of severe falciparum malaria: A randomised trial. Lancet, 366(9487), 717-725.
  12. Anstey, N.M., Weinberg, J.B., Hassanali, M.Y., Mwaikambo, E.D., Manyenga, D., Misukonis, M. A., et al. (1996). Nitric oxide in Tanzanian children with malaria: Inverse relationship between malaria severity and nitric oxide production/nitric oxide synthase type 2 expression. Journal of Experimental Medicine, 184(2), 557-567.
Click here to view more Nick Anstey publications in PubMed.
  1. Research reveals defence against malaria parasites

    Research reveals defence against malaria parasites

    Date

    The study, which has just been published in the prestigious journal Blood, was led by Associate Professor Brendan McMorran at ANU and Professor Nick Anstey at Darwin's Menzies School of Health Research

  2. Xinhuanet.com|Platelets kill up to 60 pct of malaria parasites: Australian study

    Xinhuanet.com|Platelets kill up to 60 pct of malaria parasites: Australian study

    Date

    The study, published by the Menzies School of Health Research (MSHR) in Australia's Northern Territory (NT), revealed that platelets attack and kill malaria parasites in the bloodstream.

  3. Platelets the first line of defence in malaria patients

    Platelets the first line of defence in malaria patients

    Date

    The humble platelet is usually regarded as just a tiny cell that helps the blood clot. A study just published in the prestigious journal Blood has found that platelets attack and kill malaria parasites in infected humans to reduce the number of parasites circulating in their blood.

  4. New evidence supports radical treatment of  widespread form of malaria

    New evidence supports radical treatment of widespread form of malaria

    Date

    A team of malaria experts from a large international research collaboration has today published results supporting the need for a radical cure strategy to tackle one of the most debilitating forms of malaria caused by the Plasmodium vivax parasite.

  5. Award no tall order for Matthew - Darwin Sun

    Award no tall order for Matthew - Darwin Sun

    Date

    A DARWIN scientist has been named the Young Tall Poppy Scientist of the Year in recognition of his research into a type of monkey malaria transmitted to humans via mosquitoes.

  6. NT News | Brains Trust Born

    NT News | Brains Trust Born

    Date

    Researchers at Darwin's Menzies School of Health Research will play a key role in a new push to fight the scourge of malaria in the Asia-Pacific region.

  7. Monkey malaria researcher named NT Young Tall Poppy

    Monkey malaria researcher named NT Young Tall Poppy

    Date

    Menzies School of Health Research (Menzies) clinical research fellow Dr Matthew Grigg has been named the 2017 NT Young Tall Poppy Scientist of the Year in recognition for ongoing research into Plasmodium knowlesi (P. knowlesi) malaria, a type of monkey malaria transmitted to humans via mosquitos in Southeast Asia.

  8. New Australian-led malaria research powerhouse gears up to hunt down malaria across the Asia-Pacific

    New Australian-led malaria research powerhouse gears up to hunt down malaria across the Asia-Pacific

    Date

    Australia will take a leadership role in the Asia-Pacific region in a new initiative to help our nearest neighbours rid the scourge of malaria, in a new National Health and Medical Research Council (NHMRC) Centre for Research Excellence in Malaria Elimination.

  9. Territory Q features HOT NORTH

    Territory Q features HOT NORTH

    Date

    Read about our HOT NORTH collaboration in the latest Territory Q Magazine.

  10. Adult male farmers most at risk of contracting monkey malaria in Malaysia

    Adult male farmers most at risk of contracting monkey malaria in Malaysia

    Date

    Lead author, Menzies School of Health Research research fellow, Dr Matthew Grigg has specialised in identifying and researching risk factors and treatment for P. knowlesi malaria in Sabah, Malaysian Borneo.

  11. $2m grant to combat drug resistant malaria and tuberculosis

    $2m grant to combat drug resistant malaria and tuberculosis

    Date

    A $2m research grant to work towards the prevention, control and elimination of malaria and tuberculosis (TB) in Southeast Asia and the Pacific has been awarded to a consortium led by Menzies School of Health Research, in collaboration with Burnet Institute, the Department of Foreign Affairs and Trade announced today.

  12. TerritoryQ: War on Malaria, Prof Ric Price and Prof Nicholas Anstey

    TerritoryQ: War on Malaria, Prof Ric Price and Prof Nicholas Anstey

    Date

    A medical team based in Darwin has put itself at the centre of the goal to eliminate malaria from the Asia-Pacific

  13. Menzies leaders inducted into important new health and medical academy

    Menzies leaders inducted into important new health and medical academy

    Date

    Three Menzies researchers inducted as Fellows of the newly formed Australian Academy of Health and Medical Sciences.

  14. Infectious diseases specialist honoured with prestigious Academy Award

    Infectious diseases specialist honoured with prestigious Academy Award

    Date

    One of Australiaís leading infectious diseases specialists has been recognised with a prestigious national award for his contributions in tackling the global burden of malaria.

  15. Menzies secures critical funding for malaria and tropical health research

    Menzies secures critical funding for malaria and tropical health research

    Date

    The millions of people worldwide who suffer from malaria and other tropical infections each year will benefit from the awarding of a federal fellowship to one of the country's leading clinical researchers in tropical health.