Malaria is a major cause of death in the Asia-Pacific, infecting around 250 million people each year.

The Menzies malaria research program spans a broad range of research activities aimed at both prevention and treatment, from epidemiology, diagnosis, pathophysiology, immunology, molecular parasitology, clinical trials, and evaluation of the impact and cost-effectiveness of public health interventions.

We work on all five species of the Plasmodium parasite that cause human malaria, with a particular focus on the three that cause most disease and death in the Asia-Pacific region: P. falciparum, P. vivax and P. knowlesi.

Our research focus:

• To better understand Plasmodium parasites, in particular how they become resistant to drugs, how they cause severe disease and death and how our immune system protects against them. With this knowledge, we can identify better ways to prevent and treat malaria in different environments, facilitating policy change and monitoring the impact of such change on the health of communities.

Our research impact:

• Showed that artemisinin combination therapies (ACT) have high efficacy against all species of malaria in Indonesia and Malaysia. A unified strategy of ACT for all uncomplicated malaria in Papua has led to a significant reduction in falciparum malaria, halving the risk of perinatal mortality. Clinical studies are on going to investigate better ways of using ACT in pregnancy and early life.
• Pioneered a novel laboratory test to assess new drugs against P. falciparum and P. vivax and are working with other drug discovery teams to prioritise the development of key antimalarial agents for the future.
• Observed that levels of a key protective molecule, nitric oxide, are reduced in severe falciparum malaria and that function of the very small blood vessels and the endothelial cells which line them are markedly impaired in severe falciparum malaria. This finding has helped to pioneer new adjunctive therapies to increase nitric oxide and therefore blood supply to vital organs in severe cases and these are now being trialled with partners in Asia.
• Showed P. vivax to be a major cause of severe and fatal malaria in Papua, Indonesia, primarily due to its ability to cause recurrent infections and severe anaemia. Menzies is now leading multicentred clinical trials in seven countries across the Asia-Pacific region to optimise the safe and effective use of primaquine regimens to prevent P. vivax relapse.
• Discovered a new hidden malaria lifecycle of P. vivax and P. falciparum in the human spleen, which contributes to chronic anaemia and chronic, often undetectable infections. This has significant implications for malaria elimination strategies.
• Revealed that P. knowlesi malaria incidence has increased in Sabah as the other species have been brought under control, threatening malaria elimination in areas where P. knowlesi occurs. This result was achieved through the analysis of 20 years of malaria notification data and ongoing prospective studies in collaboration with the Malaysian Ministry of Health.
• Determined that P. knowlesi malaria is three times more likely to cause severe disease than P. falciparum, but that deaths from knowlesi malaria can be avoided by early hospital referral and artesunate.

Key staff:

• Prof Nick Anstey
• Prof Ric Price
• Dr Nick Douglas
• Assoc Prof Sarah Auburn
• Dr Gabriela Minigo
• Kim Piera
• Dr Steven Kho
• Assoc Prof Kamala Thriemer
• Dr Benedikt Ley
• Assoc Prof Matthew Grigg
• Dr Rob Commons
• Dr Angela Devine
• Dr Holger Unger
• Dr Mariana Barnes
• Angela Rumaseb

Honorary Fellows:

• Dr Jutta Marfurt 
• Assoc Prof Bridget Barber 

Students:​

• Daniel Pfieffer
• Varunika Ruwanpura
• Angelica Tan
• Dr Liony Fransisca
• Sarah Cassidy-Seyoum
• Muthoni Mwaura
• Hidayat Trimarsanto
• Arkasha Sadhewa
• Elvin Lufele
• Eri Setiawan

Collaborators:

Australian:

• Australian Army Malaria Institute
• Griffith University
• Queensland Institute of Medical Research
• Burnet Institute
• University of Melbourne
• James Cook University
• University of Sydney
• University of Western Australia
• Walter and Eliza Hall Institute

International

• Asia-Pacific Malaria Elimination Network
• District Health Authority, Papua, Indonesia
• Eijkman Institute for Molecular Biology, Indonesia
• Papuan Community Health and Development Foundation, Timika, Indonesia
• University Gadjah Mada, Indonesia
• University of North Sumatra, Indonesia 
• Queen Elizabeth Hospital and Ministry of Health, Malaysia
• University of Otago, New Zealand
• Herbert Kairuki Memorial University, Tanzania
• Arba Minch University, Ethiopia
• Mahidol-Oxford Research Unit, Bangkok, Thailand
• Centre of Tropical Medicine, Oxford University, United Kingdom
• London School of Hygiene and Tropical Medicine, United Kingdom
• Duke University, United States 

Clinical Trials

• Advancing the radical cure of Plasmodium vivax malaria through optimal antimalarial regimens
• EFFORT clinical trial: Effectiveness of tafenoquine and primaquine
• PRIMA clinical trial: Universal Radical Cure of P. vivax malaria
• SIRIN Clinical Trial: Radical cure of P. vivax malaria in Nepal 
• IMPROV Study: Shorter treatment regimen for radical cure of P.Vivax malaria
• PACKNOW: Paracetamol to ameliorate acute kidney injury in knowlesi malaria
• ZOOMAL - Evaluating zoonotic malaria transmission and agricultural land use in Indonesia
• SAPOT Clinical Trial: Treatment in pregnancy to prevent malaria
• TADORE study: A revised tafenoquine dose to improve radical cure for vivax malaria

Epidemiology

• IMPACT Study: The impact of symptomatic P.vivax infection on G6PD activity
• vivaxGEN: Molecular surveillance of P. vivax
• ACROSS Study: Populations at risk of malaria and drug induced haemolysis
• HOT NORTH
• ZOOMAL: Surveillance for zoonotic malaria in Indonesia
• Sabah malaria surveillance study 

Pathophysiology

• Pathogenesis of falciparum, vivax and knowlesi malaria
• Timika SPLEEN studies

Stronger Health and Research Systems

• Stronger Health Systems for multidrug-resistant tuberculosis and malaria
• The Vivax Working Group of the Asia Pacific Malaria Elimination Network (APMEN)
• The Tropical Disease Regional Research Regional Collaborative Initiative: Responding to Drug-Resistant Tuberculosis and Malaria in the Asia-Pacific 

Health Economics and Modelling 

• Multi-species malaria modelling to improve policy and decision making

Click here to view more malaria publications in PubMed.

Key publications in 2019

1. Kho, S., Andries, B., Poespoprodjo, J.R., Commons, R.J., Shanti, P.A.I., Kenangalem E, Douglas NM, Simpson JA, Sugiarto P, Anstey N.M. ​​& ​Price, R.N. (2019). High risk of Plasmodium vivax malaria following splenectomy in Papua, Indonesia. Clinical Infectious Diseases, 68(1):51-60. doi: 10.1093/cid/ciy403.
2. Commons, R.J., Simpson, J.A., Thriemer, K., Hossain, M.S., Douglas, N.M., Humphreys, G.S., Sibley, C.H., Guerin, P.J. & Price, R.N. (2019). The risk of Plasmodium vivax parasitaemia after P. falciparum infection: a systematic review and meta-analysis. Lancet Infectious Diseases, 19: 91-101. doi: 10.1016/S1473-3099(18)30596-6.
3. Yeo, T.W., Weinberg, J.B., Lampah, D.A., Kenangalem, E., Bush, P., Chen, Y., Price,, R.N., Young, S., Zhang, H.Y., Millington, D., Granger, D.L. & Anstey, N.M. (2019). Glycocalyx Breakdown is Associated with Severe Disease and Fatal Outcome in Plasmodium falciparum Malaria. Clinical Infectious Diseases, 69(10): 1712-1720. doi: 10.1093/cid/ciz038.
4. Kenangalem, E., Poespoprodjo, J.R., Douglas, N.M., Burdam, F.H., Gdeumana, K., Chalfein, F., Prayoga, Thio, F., Devine, A., Marfurt, J., Waramori, G., Yeung, S., Noviyanti, R., Penttinen, P., Bangs, M.J., Sugiarto, P., Simpson, J.A., Soenarto, Y., Anstey, N.M. &, Price, R.N. (2019). Malaria morbidity and mortality following introduction of a universal policy of artemisinin-based treatment for malaria in Papua, Indonesia: a longitudinal surveillance study. PLoS Medicine 16(5): e1002815. doi: 10.1371/journal.pmed.1002815.
5. Taylor, W.R.J., Thriemer, K., von Seidlein, L., Yuentrakul, P., Assawariyathipat, T., Assefa, A., Auburn, S., Chand, K., Chau, N.H., Cheah, P.Y. Dong, L.T., Dhorda, M., Degaga, T.S., Devine, A., Ekawati, L.L., Fahmi, F., Hailu, A., Hasanzai, M.A., Hien, T.T. ... Price, R.N. (2019). Short course primaquine for the radical cure of Plasmodium vivax malaria: a randomised placebo-controlled multicentre trial. The Lancet, 394: 929–38. doi: 10.1016/S0140-6736(19)31285-1.
6. Commons, R.J., Simpson, J.A., Thriemer, K., Chu, C.S., Douglas, N.M., Abreha, T., Alemu, S.G., Anez, A., Anstey, N.M., Aseffa, A., Aseffa, A., Awab, G.R., Baird, J.K., Barber, B.E., Borghini-Fuhrer, I., D'Alessandro, U., Dahal, P., Daher, A., de Vries, P.J., ... Price, R.N. (2019). The haematological consequences of Plasmodium vivax malaria after chloroquine treatment with and without primaquine: a WorldWide Antimalarial Resistance Network systematic review and individual patient data meta-analysis. BMC Medicine, 17:151. doi: 10.1186/s12916-019-1386-6.
7. Commons, R.J., Simpson, J.A., Thriemer, K., Abreha, T., Adam, I., Anstey, N.M., Assefa, A., Awab, G.R., Baird, J.K., Barber, B.E., Chu, C.S., Dahal, P., Daher, A., Davis, T.M.E., Dondorp, A.M., Grigg, M.J., Humphreys, G.S., Hwang, J., Karunajeewa, H., ... Price, R.N. (2019). The efficacy of dihydroartemisinin-piperaquine and artemether-lumefantrine with and without primaquine on Plasmodium vivax recurrence: a systematic review and individual patient data meta-analysis. PLoS Medicine, 16(10): e1002928. doi: 10.1371/journal.pmed.1002928.
8. Rajahram, G.S., Cooper, D.J., William, T., Grigg, M.J., Anstey, N.M. & Barber, B.E. (2019). Deaths from Plasmodium knowlesi malaria: case series and systematic review. Clinical Infectious Diseases, 69(10): 1703–1711. doi: 10.1093/cid/ciz011. 
9. Cooper, D.J., Rajahram, G.S., William, T., Jelip, J., Mohammad, R., Benedict, J., Alaza, D.A., Malacova, E., Yeo, T.W., Grigg, M.J., Anstey, N.M. & Barber, B.E. (2020). Plasmodium knowlesi malaria in Sabah, Malaysia, 2015-2017: ongoing increase in incidence despite near-elimination of the human-only Plasmodium species. Clinical Infectious Diseases, 70(3): 361–367. doi: 10.1093/cid/ciz237.
10. Kho, S., Minigo, G., Andries, B., Leonardo, L., Prayoga, P., Poespoprodjo, J.R., Kenangalem, E., Price, R.N., Woodberry, T., Anstey, N.M. & Yeo, T.W.. (2019). Circulating neutrophil extracellular traps and neutrophil activation are increased in proportion to disease severity in human malaria. The Journal of Infectious Diseases, 219(12): 1994–2004. doi: 10.1093/infdis/jiy661.
11. Barber, B.E., Grigg, M.J., Piera, K., Amante, F.H., William, T., Boyle, M.J., Minigo, G., Dondorp, A.M., McCarthy, J.S. & Anstey, N.M. (2019). Antiphosphatidylserine IgM and IgG antibodies are higher in vivax than falciparum malaria, and associated with early anemia in both species. The Journal of Infectious Diseases, 220(9): 1435–1443. doi: 10.1093/infdis/jiz334.

Selected recent publications (2017-2020)

Clinical trials, meta-analyses and systematic reviews

1. Abreha, T., Hwang, J., Thriemer, K., Tadesse, Y., Girma, S., Melaku, Z., Assefa, A., Kassa, M., Chatfield, M.D., Landman, K.Z., Chenet, S.M., Lucchi, N.W., Udhayakumar, V., Zhou, Z., Shi, Y.P., Kachur, S.P., Jima, D., Kebede, A., Solomon, H. ... Price, R.N. (2017). Comparison of artemether-lumefantrine and chloroquine with and without primaquine for the treatment of Plasmodium vivax in Ethiopia: a randomized controlled trial. PLoS Medicine, 14(5) e1002299. doi: 10.1371/journal.pmed.1002299.
2. Grigg, M.J., William, T., Piera, K.A., Rajahram, G.S., Jelip, J., Aziz, A., Menon, J., Marfurt, J., Price, R.N., Auburn, S., Barber, B.E., Yeo, T.W.  & Anstey, N.M. (2017). Plasmodium falciparum artemisinin resistance monitoring in Sabah, Malaysia: in vivo therapeutic efficacy and kelch13 molecular marker surveillance. Malaria Journal, 17(1):463. doi: 10.1186/s12936-018-2593-x.
3. Commons, R.J., Simpson, J.A., Thriemer, K., Humphreys, G.S., Abreha, T., Alemu, S.G., Anez, A., Anstey, N.M, Awab, G.R., Baird, J.K., Barber, B.E., Borghini-Fuhrer, I., Chu, C.S., D'Alessandro, U., Dahal, P., Daher, A., de Vries, P.J., Erhart, A, Gomes, M.S.M. ... & Price, R.N. (2018). The effect of chloroquine dose and primaquine on Plasmodium vivax recurrence: a WorldWide Antimalarial Resistance Network systematic review and individual patient pooled meta-analysis. Lancet Infectious Diseases, 18(9): 1025-1034. doi: 10.1016/S1473-3099(18)30348-7. 
4. Grigg, M.J., William, T., Barber, B.E., Rajahram, G.S., Menon, J., Schimann, E., Wilkes, C.S., Patel, K., Chandna, A., Price, R.N., Yeo, T.W. & Anstey, N.M. (2018). Artemether-lumefantrine versus chloroquine for the treatment of uncomplicated Plasmodium knowlesi malaria: an open-label randomized controlled trial (CAN KNOW). Clinical Infectious Diseases, 66(2): 229-236. doi: 10.1093/cid/cix779.
5. Commons, R.J., Simpson, J.A., Thriemer, K., Hossain, M.S., Douglas, N.M., Humphreys, G.S., Sibley, C.H., Guerin, P.J. & Price, R.N. (2019). The risk of Plasmodium vivax parasitaemia after P. falciparum infection: a systematic review and meta-analysis. Lancet Infectious Diseases, 19: 91-101. doi: 10.1016/S1473-3099(18)30596-6.
6. Taylor, W.R.J., Thriemer, K., von Seidlein, L., Yuentrakul, P., Assawariyathipat, T., Assefa, A., Auburn, S., Chand, K., Chau, N.H., Cheah, P.Y. Dong, L.T., Dhorda, M., Degaga, T.S., Devine, A., Ekawati, L.L., Fahmi, F., Hailu, A., Hasanzai, M.A., Hien, T.T. ... Price, R.N. (2019). Short course primaquine for the radical cure of Plasmodium vivax malaria: a randomised placebo-controlled multicentre trial. The Lancet, 394: 929–38. doi: 10.1016/S0140-6736(19)31285-1.
7. Commons, R.J., Simpson, J.A., Thriemer, K., Abreha, T., Adam, I., Anstey, N.M., Assefa, A., Awab, G.R., Baird, J.K., Barber, B.E., Chu, C.S., Dahal, P., Daher, A., Davis, T.M.E., Dondorp, A.M., Grigg, M.J., Humphreys, G.S., Hwang, J., Karunajeewa, H., ... Price, R.N. (2019). The efficacy of dihydroartemisinin-piperaquine and artemether-lumefantrine with and without primaquine on Plasmodium vivax recurrence: a systematic review and individual patient data meta-analysis. PLoS Medicine, 16(10): e1002928. doi: 10.1371/journal.pmed.1002928. 
8. Commons, R.J., Simpson, J.A., Thriemer, K., Chu, C.S., Douglas, N.M., Abreha, T., Alemu, S.G., Añez, A., Anstey, N.M., Aseffa, A., Aseffa, A., Awab, G.R., Baird, J.K., Barber, B.E., Borghini-Fuhrer, I., D'Alessandro, U., Dahal, P., Daher, A., de Vries, P.J., Erhart, A., ... Price, R.N. (2019). The haematological consequences of Plasmodium vivax malaria after chloroquine treatment with and without primaquine: a WorldWide Antimalarial Resistance Network systematic review and individual patient data meta-analysis. BMC Medicine, 17:151. doi: 10.1186/s12916-019-1386-6
9. Ahmed, R., Poespoprodjo, J.R., Syafruddin, D., Khairallah, C., Pace, C., Lukito, T., Maratina, S.S., Asih, P.B.S., Santana-Morales, M.A., Adams, E.R., Unwin, V.T., Williams, C.T., Chen, T., Smedley, J., Wang, D., Faragher, B., Price, R.N.& ter Kuile, F.O. (2019). Efficacy and safety of Intermittent preventive treatment (IPT), intermittent screening and treatment (IST) and single screening and treatment (SST) with dihydroartemisinin-piperaquine for the control of malaria in pregnancy in Indonesia: An open label cluster-randomized controlled trial. Lancet Infectious Diseases, 19 (9), 973-987. doi: 10.1016/S1473-3099(19)30156-2.

Clinical spectrum and diagnosis

1. Grigg, M.J., William, T., Barber, B.E., Rajahram, G.S., Menon, J., Schimann, E., Piera, K., Wilkes, C.S., Patel, K., Chandna, A., Drakeley, C.J., Yeo, T.W. & Anstey, N.M. (2018). Age-related clinical spectrum of Plasmodium knowlesi malaria and predictors of severity. Clinical Infectious Diseases 67(3): 350-359. doi: 10.1093/cid/ciy065.
2. Aung, N.M., Nyein, P.P., Htut, T.Y., Htet, Z.W., Kyi, T.T., Anstey, N.M, Kyi, M.M. & Hanson, J. (2018). Antibiotic Therapy in Adults with Malaria: High Rate of Clinically Significant Bacteremia in Hospitalized Adults Diagnosed with Falciparum Malaria. The American Journal of Tropical Medicine and Hygiene, 99(3): 688–696. doi:10.4269/ajtmh.18-0378. 
3. Kho, S., Andries, B., Poespoprodjo, J.R., Commons, R.J., Shanti, P.A.I., [...], Anstey, N.M, Price, R.N. (2019). High risk of Plasmodium vivax malaria following splenectomy in Papua, Indonesia. Clinical Infectious Diseases, 68(1): 51-60. doi: 10.1093/cid/ciy403.
4. Rajahram, G.S., Cooper, D.J., William, T., Grigg, M.J., Anstey, N.M. & Barber, B.E. (2019). Deaths from Plasmodium knowlesi malaria: case series and systematic review. Clinical Infectious Diseases, 69(10):1703–1711. doi:10.1093/cid/ciz011.
5. Ley, B., Satyagraha, A.W., Rahmat, H., von Fricken, M.E., Douglas, N.M., Pfeffer, D.A., Espino, F.E., von Seidlein, L., Henriques, G., Oo, N.N., Menard, D., Parikh, S., Bancone, G., Karahalios, A. & Price RN.  (2019) Performance of the Accessbio/Carestart rapid diagnostic test for the detection of glucose 6 phosphate dehydrogenase deficiency: a systematic review and meta-analysis. PLoS Medicine, 16(12): e1002992. doi: 10.1371/journal.pmed.1002992

Epidemiology, surveillance and health economics 

1. Grigg, M.J., Cox, J., William, T., Jelip, J., Fornace, K.M., Brock, P.M., von Seidlein, L., Barber, B.E., Anstey, N.M, Yeo, T.W. & Drakeley, C.J. (2017). Individual factors associated with the risk of acquiring human Plasmodium knowlesi malaria in Malaysia: a case-control study. Lancet Planet Health, 1(3), e97–e104. doi: 10.1016/S2542-5196(17)30031-1.
2. Trimarsanto, H., Benavente, E.D., Noviyanti, R., Utami, R.A.S., Getachew, S., Kim, J.Y., Goo, Y.K., Wangchuck, S., Liu, Y., Gao, Q., Dowd, S., Cheng, Q., Clark, T.G., Price, R.N. & Auburn, S. (2017). VivaxGEN: A Platform for Comparative Analysis of Short Tandem Repeat Genotyping Data in Plasmodium vivax Populations. PLoS Neglected Tropical Diseases, 11(3): e0005465. doi: 10.1371/journal.pntd.0005465.
3. Devine, A., Parmiter, M., Chu, C.S., Bancone, G., Nosten, F., Price, R.N., Lubell, Y. & Yeung, S. (2017). Using G6PD Tests to Enable the Safe Treatment of Plasmodium vivax Infections with Primaquine on the Thai-Myanmar border: a Cost-Effectiveness Analysis. PLoS Neglected Tropical Diseases, 11(5):e0005602. doi: 10.1371/journal.pntd.0005602.
4. Douglas, N.M., Poespoprodjo, J.R., Patriani, D., Malloy, M.J., Kenangalem, E., Sugiarto, P., Simpson, J.A., Soenarto, Y., Anstey, N.M. & Price, R.N. (2017). Unsupervised primaquine for the treatment of Plasmodium vivax malaria relapses in southern Papua: a hospital-based cohort study. PLoS Medicine, 14(8): e1002379. doi: 10.1371/journal.pmed.1002379. 
5. Auburn, S., Benavente, E.D., Miotto, O., Pearson, R.D., Amato, R., Grigg, M.J., Barber, B.E., William, T., Handayuni, I., Marfurt, J., Trimarsanto, H., Noviyanti, R., Sriprawat, K., Nosten, F., Campino, S., Clark, T.G.,Anstey, N.M, Kwiatkowski, D.P. & Price, R.N. (2018). Genomic analysis of a pre-elimination Malaysian Plasmodium vivax population reveals selective pressures and changing transmission dynamics. Nature Communications, 9(1): 2585. doi: 10.1038/s41467-018-04965-4. 
6. Kenangalem, E., Poespoprodjo, J.R., Douglas, N.M., Burdam, F.H., Gdeumana, K., Chalfein, F., Prayoga, Thio, F., Devine, A., Marfurt, J., Waramori, G., Yeung, S., Noviyanti, R., Penttinen, P., Bangs, M.J., Sugiarto, P., Simpson, J.A., Soenarto, Y., Anstey, N.M. &, Price, R.N. (2019). Malaria morbidity and mortality following introduction of a universal policy of artemisinin-based treatment for malaria in Papua, Indonesia: a longitudinal surveillance study. PLoS Medicine 16(5): e1002815. doi: 10.1371/journal.pmed.1002815.
7. Auburn, S., Getachew, S., Pearson, R.D., Amato, R., Miotto, O., Trimarsanto, H., Zhu, S.J., Rumaseb, A., Marfurt, J., Noviyanti, R., Grigg, M.J., Barber, B., William, T., Goncalves, S.M., Drury, E., Sriprawat, K., Anstey, N.M., Nosten, F., Petros, B., ... & Price, R.N. (2019). Genomic analysis of Plasmodium vivax in southern Ethiopia reveals selective pressures in multiple parasite mechanisms. Journal of Infectious Diseases, 220:1738-49. doi: 10.1093/infdis/jiz016
8. Devine, A., Pasaribu, A.P., Teferi, T., Pham, H.T., Awab, G.R., Contantia, F., Nguyen, T.N., Ngo, V.T., Tran, T.H., Hailu, A., Gilchrist, K., Green, J.A., Koh, G., Thriemer, K., Taylor, W.R.J., Day, N.P.J., Price, R.N. & Lubell, Y. (2019). Provider and household costs of Plasmodium vivax malaria episodes: a multicountry comparative analysis of primary trial data. Bulletin of WHO, 97(12):828–836. doi: 10.2471/BLT.18.226688 
9. Cooper, D.J., Rajahram, G.S., William, T., Jelip, J., Mohammad, R., Benedict, J., Alaza, D.A., Malacova, E., Yeo, T.W., Grigg, M.J., Anstey, N.M & Barber, B.E. (2020). Plasmodium knowlesi malaria in Sabah, Malaysia, 2015-2017: ongoing increase in incidence despite near-elimination of the human-only Plasmodium species. Clinical Infectious Diseases, 70(3): 361–367. doi: 10.1093/cid/ciz237

Pathogenesis and immunology 

1. Barber, B.E., Grigg, M.J., William, T., Piera, K.A., Boyle, M., Yeo, T.W. & Anstey, N.M. (2017). Effects of Aging on Parasite Biomass, Inflammation, Endothelial Activation, Microvascular Dysfunction and Disease Severity in Plasmodium knowlesi and Plasmodium falciparum Malaria. Journal Infectious Diseases, 215(12): 1908-1917. doi: 10.1093/infdis/jix193.
2. Kho, S., Barber, B.E., Johar, E., Andries, B., Poespoprodjo, J.R., Kenangalem, E., Piera, K.A., Ehmann, A., Price, R.N., William, T., Woodberry, T., Foote, S., Minigo, G., Yeo, T.W., Grigg, Anstey, N.M. & McMorran, B. (2018). Platelets kill circulating parasites of all major Plasmodium species in human malaria. Blood, 132(12):1332-1344. doi:10.1182/blood-2018-05-849307.
3. Oyong, D.A., Kenangalem, E., Poespoprodjo, J.R., Beeson, J.G., Anstey, N.M. Price, R.N. & Boyle, M.J. (2018). Loss of complement regulatory proteins on uninfected erythrocytes in vivax and falciparum malaria anemia. JCI Insight, 3(22): 124854. doi: 10.1172/jci.insight.124854.
4. Barber, B.E., Grigg, M.J., Piera, K.A., William, T., Cooper, D.J., Plewes, K., Dondorp, A.M., Yeo, T.W. & Anstey, N.M. (2018). Intravascular haemolysis in severe Plasmodium knowlesi malaria: association with endothelial activation, microvascular dysfunction, and acute kidney injury. Emerging Microbes Infection, 7(1):106. doi: 10.1038/s41426-018-0105-2.
5. Barber, B.E., Russell, B., Grigg, M.J., Zhang, R., William, T., Amir, A., Lau, Y.L., Chatfield, M.D., Dondorp, A.M. & Yeo, T.W. (2018). Reduced red blood cell deformability in Plasmodium knowlesi malaria. Blood Advances, 2(4): 433-443. doi: 10.1182/bloodadvances.2017013730.
6. Kho, S., Minigo, G., Andries, B., Leonardo, L., Prayoga, P., Poespoprodjo, J.R., Kenangalem, E., Price, R.N., Woodberry, T., Anstey, N.M. & Yeo, T.W. (2019). Circulating neutrophil extracellular traps and neutrophil activation are increased in proportion to disease severity in human malaria. The Journal of Infectious Diseases, 219(12):1994–2004. doi:10.1093/infdis/jiy661.
7. Yeo, T.W., Weinberg, J.B., Lampah, D.A., Kenangalem, E., Bush, P., Chen, Y., Price, R.N., Young, S., Zhang, H.Y., Millington, D., Granger, D.L. & Anstey, N.M. (2019). Glycocalyx Breakdown is Associated with Severe Disease and Fatal Outcome in Plasmodium falciparum Malaria. Clinical Infectious Diseases, 69(10): 1712–1720. doi:10.1093/cid/ciz038.
8. Loughland, J.R., Woodberry, T., Boyle, M.J., Tipping, P.E., Piera, K.A., Amante, F.H., Kenangalem, E., Price, R.N., Engwerda, C.R., Anstey, N.M., McCarthy, J.S. & Minigo G. (2019) Plasmodium falciparum activates CD16+ dendritic cells to produce TNF and IL-10 in subpatent malaria. Journal of Infectious Diseases, 219(4): 660-671. doi: 10.1093/infdis/jiy555.
9. Barber, B.E., Grigg, M.J., Piera, K., Amante, F.H., William, T., Boyle, M.J., Minigo, G., Dondorp, A.M., McCarthy, J.S. & Anstey, N.M. (2019). Anti-phosphatidylserine IgM and IgG antibodies are higher in vivax than falciparum malaria, and associated with early anemia in both species. Journal of Infectious Diseases, 220(9):1435–1443. doi:10.1093/infdis/jiz334.