Professor Amanda Jane Leach
Principal research fellow; Leader of the Ear Health Research Program, Child Health Division
Master of Agricultural Science; PhD (Medicine).
Approved level of HDR supervision at Charles Darwin University:
Principal Supervisor for PhD
Professor Amanda Leach is leader of the Ear Health Research Program, Child Health Division. She won a 2004 National Health and Medical Research Council Career Development Award and in 2011 a Senior Research Fellowship which was awarded the Elizabeth Blackburn Fellowship for top ranking female applicant in the clinical category.
Professor Leach has 76 career publications; her 1994 PhD publication (cited by 297) described for the first time that Indigenous infants acquire nasopharyngeal bacterial pathogens (Pneumococcus, non-typeable H. influenzae and M. catarrhalis) within weeks of life and that acquisition predicted onset of otitis media (OM). Professor Leach also reported the impact of mass azithromycin treatment for trachoma eradication on pneumococcal resistance (Leach et al. 1997; cited by 243).
Prof Leach leads a NHMRC Centre of Research Excellence in Ear and Hearing Health of Aboriginal and Torres Strait Islander children, CRE_ICHEAR, 2014 to 2019. She is also lead investigator for two vaccine trials and a study of school readiness, and is co-investigator on two NHMRC clinical trials for treatment of OM in urban Aboriginal children (WATCH and INFLATE).
Prof Leach is also leading a major project of the CRE_ICHEAR, to apply the GRADE approach to update the 2010 OM Guidelines for launch in 2017, including an OM app.
- VOICES - Vaccines to prevent Otitis media In Children Entering School
- Centre for Research Excellence in Indigenous Children’s Healthy Ears (ICHEAR)
- Immunogenicity, carriage and otitis media outcomes of pneumococcal conjugate vaccines PHiD-CV and 13PCV in sequence or alone in high-risk Indigenous infants: a randomised controlled trial (PREV-IX_COMBO)
- Pneumococcal conjugate vaccine (PCV) schedules for the Northern Territory (NT): randomised controlled trial of booster vaccines to broaden and strengthen protection from invasive and mucosal infections (Study name: PREV-IX_BOOST)
- Developing more accurate measures of immune response and vaccine efficacy of standard and novel schedules of two new pneumococcal conjugate vaccines (Prevenar13 or Synflorix) in Indigenous infants
- Monitoring Prevenar13 impact on otitis media and respiratory pathogen carriage, with particular focus on pneumococcal diversity, in Australian Indigenous children post-PCV13 introduction to the NIP
- Randomised controlled trial of watchful waiting versus antimicrobial treatment waiting for acute otitis media without perforation in low risk Aboriginal children.
- Hare, K.M., Marsh, R.L., Binks, M.J., Grimwood, K., Pizzutto, S.J., Leach, A.J., Chang, A.B. & Smith-Vaughan, H.C. (2013). Quantitative PCR confirms culture as the gold standard for detection of lower airway infection by nontypeable Haemophilus influenzae in Australian Indigenous children with bronchiectasis. Journal of Microbiological Methods, 92(3), 270-272.
- Marsh, R.L., Binks, M.J., Beissbarth, J., Christensen, P., Morris, P.S., Leach, A.J. & Smith-Vaughan, H.C. (2012). Quantitative PCR of ear discharge from Indigenous Australian children with acute otitis media with perforation supports a role for Alloiococcus otitidis as a secondary pathogen. BMC Ear, Nose and Throat Disorders, 12, 11.
- Binks, M.J., Temple, B., Kirkham, L.A., Wiertsema, S.P., Dunne, E.M., Richmond, P.C., Marsh, R.L., Leach, A.J. & Smith-Vaughan, H.C. (2012). Molecular surveillance of true nontypeable Haemophilus influenzae: an evaluation of PCR screening assays. PLoS One, 7(3), e34083.
- McAllister, L.J., Ogunniyi, A.D., Stroeher, U.H., Leach, A.J. & Paton, J.C. (2011). Contribution of serotype and genetic background to virulence of serotype 3 and serogroup 11 pneumococcal isolates. Infection and Immunity, 79(12), 4839-4849.
- Hare, K.M., Smith-Vaughan, H.C. & Leach, A.J. (2011). Viability of respiratory pathogens cultured from nasopharyngeal swabs stored for up to 12 years at -70°C in skim milk tryptone glucose glycerol broth. Journal of Microbiological Methods, 86(3), 364-367.
- Binks, M.J., Cheng, A.C., Smith-Vaughan, H., Sloots, T., Nissen, M., Whiley, D., McDonnell, J. & Leach, A.J. (2011). Viral-bacterial co-infection in Australian Indigenous children with acute otitis media. BMC Infectious Diseases, 11, 161.
- Jacoby, P., Carville, K.S., Hall, G., Riley, T.V., Bowman, J., Leach, A.J., Lehmann, D. & the Kalgoorlie Otitis Media Research Project Team. (2011). Crowding and other strong predictors of upper respiratory tract carriage of otitis media-related bacteria in Australian Aboriginal and non-Aboriginal children. Pediatric Infectious Disease Journal, 30(6), 480-485.
- Harvey, R.M., Stroeher, U.H., Ogunniyi, A.D., Smith-Vaughan, H.C., Leach, A.J. & Paton, J.C. (2011). A variable region within the genome of Streptococcus pneumoniae contributes to strain-strain variation in virulence. PLoS One, 6(5), e19650.
- Jacups, S.P., Morris, P.S. & Leach, A.J. (2011). Haemophilus influenzae type b carriage in Indigenous children and children attending childcare centers in the Northern Territory, Australia, spanning pre- and post-vaccine eras. Vaccine, 29(16), 3083-3088.
- Slade, G.D., Bailie, R.S., Roberts-Thomson, K., Leach, A.J., Raye, I., Endean, C., Simmons, B. & Morris, P. (2011). Effect of health promotion and fluoride varnish on dental caries among Australian Aboriginal children: results from a community-randomized controlled trial. Community Dentistry and Oral Epidemiology, 39(1), 29-43.
Click here to view more Amanda Leach publications in PubMed.
RN Life Matters - In many Indigenous communities, middle ear infections are rife, leading to hearing problems and a life of disadvantage.
Otitis Media - a clinical trial where Indigenous infants will receive an extra dose of pneumococcal vaccine to try and cut down the rates of incidence.
Menzies School of Health researchers are hoping to reduce rates of a chronic ear disease called Otis Media, in remote indigenous communities. (Image source: creative commons)
The Menzies School of Health Research is conducting a clinical trial in remote communities in the Northern Territory and Western Australia, and hope the results will change the public health approach and give more help to families.
In a world first, Northern Territory researchers are trialling a new treatment to heal an ear disease plaguing Indigenous communities and causing lifelong disadvantage.
Innovation and transformation are at the heart of the Menzies School of Health Research (Menzies) projects which have secured funding in the highly competitive NHMRC grant round.
Bulging ear drums and hearing loss: Aboriginal kids have the highest otitis media rates in the world
This article is the final in our three-part series on blinding, deafening and sometimes deadly conditions in Indigenous Australian children that have little to no impact on their non-Indigenous counterparts.
LEADING ear health experts at Menzies School of Health Research (Menzies) are calling for more investment in the prevention and treatment of ear disease and hearing loss among Indigenous children.
What is the relationship between lifelong hearing loss and Indigenous incarceration? A powerful story to mark Hearing Awareness Week
What profound impact could be had on high rates of Aboriginal and Torres Strait Islander incarceration by ensuring better hearing for children and adults? It’s an important question raised in this moving post below, to mark Hearing Awareness Week, from Sam Harkus, Principal Audiologist, Aboriginal & Torres Strait Islander Services.
In recognition of Hearing Awareness Week (August 21-27), leading ear health experts at Menzies School of Health Research (Menzies) are calling for more investment in the prevention and treatment of ear disease and hearing loss in Aboriginal and Torres Strait Islander children.
A leading ear and hearing health collaborative research program led by Menzies was today declared a ‘Centre of Research Excellence (CRE)’ and awarded funding of $2.5 million over five years.
Aboriginal health worker Joe Daby has seen the worst when it comes to ear health in Territory communities.
An opportunity to hear from leading Indigenous health experts about inventive new ways they are closing the gap is set to draw some of the Territory’s most influential and iconic identities for a formal charity breakfast.
Two researchers from Menzies School of Health Research were recognised for their contribution to the science community at the National Health and Medical Research Council (NHMRC) Gala Dinner held at Parliament House in Canberra last night.