Professor Anne Chang AM
Senior Principal Research Fellow, Head of the Child Health Respiratory Program, Head of the Child and Maternal Health Division
Bachelor of Medicine and Bachelor of Surgery, University of Melbourne, 1988 (MBBS); Master of Public Health and Tropical Medicine, James Cook University, 2000 (MPHTM); PhD, University of Melbourne, 1998 (PhD); Fellow, Royal Australasian College of Physicians, 1995 (FRACP); Fellow, Thoracic Society of Australia and New Zealand (FThorSoc); Fellow, Asian Pacific Society of Respirology, 2013; Fellow, Australian Academy of Health and Medical Science (FAHMS)
Approved level of HDR supervision at Charles Darwin University:
Principal Supervisor for PhD
Professor Anne Chang AM is an established leading researcher with international recognition in cough, bronchiectasis and evidence-based medicine (EBM) related to paediatric respiratory medicine. She has helped develop and apply EBM for respiratory illnesses nationally and internationally. She is the editor of two EBM series, one on respiratory medicine and the other on Indigenous health.
Professor Chang is also responsible for changing paradigms in the investigation and management of paediatric cough leading to earlier diagnosis of bronchiectasis, describing a pre-bronchiectasis condition (PBB), the inclusion of respiratory symptoms in primary care child assessments (Northern Territory and Queensland) and the establishment of the first international Indigenous collaborative respiratory study.
- Child and Maternal Health
- Respiratory Health
- PneuMatters Study: Preventing early-onset pneumonia in children through maternal immunisation: a multi-centre randomised control trial (RCT)
- PARROT: Prophylactic antibiotics to prevent recurrent lower respiratory tract infections in children with neurological
- impairment study.
- REPEAT: Improving outcomes of children and young adults with primary ciliary dyskinesia: a multi-centre, double-blind, double dummy, 2x2 factorial, randomised controlled trial (RCT).
- CRE-Aus_BREATHE: Centre of Research Excellence in preventing and managing bronchiectasis, especially in Aboriginal and Torres Strait Islander Children.
- Australian Bronchiectasis Registry
- Preventing recurrent acute lower respiratory infections (PETAL) study: a multi-centre randomised controlled trial
- Hospitalised Pneumonia with Extension Treatment study (HOPE): a multi-centre randomised controlled trial
- Bronchiectasis Action Management Plan (BAMP) Study: a multi-centre randomised controlled trial
- Short and long-term effects of therapeutic exercise in children with bronchiectasis: a multi-centre randomised controlled trial (BREATH)
- The Patho-micro-biology of protracted bacterial bronchitis and chronic suppurative lung disease in children
- Aboriginal and Torres Strait Islander Partnerships to Prevent Permanent Disease (APPLE Study)
- Oral bacterial lysate to prevent persistent wheeze in infants after severe bronchiolitis; a randomised placebo-controlled trial (BLIPA-AUS)
- BronchiEctasis Trial Testing ERdosteine (BETTER)
- Development and internal validation of the paediatric pneumonia severity (PEPS) score
- Ruffles TJC, Goyal V, Marchant JM, Masters IB, Yerkovich ST, Buntain HM, Cook A, Schultz A, Upham JW, Champion A, Versteegh L, Chang AB. Duration of amoxicillin-clavulanate for protracted bacterial bronchitis in children (DACS): a multi-centre, double blind, randomised controlled trial. Lancet Respir Med. 2021; 9(10):1121-1129. doi: 10.1016/S2213-2600(21)00104-1.
- O'Grady KF, Grimwood K, Torzillo PJ, Rablin S, Lovie-Toon Y, Kaus M, Arnold D, Roberts J, Buntain H, Adsett D, King A, Scott M, Anderson J, Toombs M, Chang AB. Effectiveness of a chronic cough management algorithm at the transitional stage from acute to chronic cough in children: a multi-centre randomised controlled trial. Lancet Child & Adolescent Health 2019;3:889-98
- Goyal V, Grimwood K, Ware RS, Byrnes CA, Morris PS, Masters IB, McCallum GB, Binks MJ, Marchant JM, Smith-Vaughan HS, O'Grady KF, Champion A, Buntain H, Schultz A, Chatfield M, Torzillo PJ, Chang AB. Efficacy of oral antibiotics for non-severe exacerbations of bronchiectasis in children (BEST 1): A multi-centre, double-blind, double-dummy, randomised placebo-controlled trial. Lancet Respir Med. 2019; 7(9):791-801. doi: 10.1016/S2213-2600(19)30254-1.
- Goyal V, Grimwood K, Byrnes CA, Morris PS, Masters IB, Ware RS, McCallum GB, Binks MJ, Marchant JM, Van Asperen PP, O'Grady KF, Champion A, Buntain H, Petsky H, Torzillo PJ, Chang AB. Amoxicillin-clavulanate versus azithromycin for respiratory exacerbations in children with bronchiectasis (BEST-2): A multi-centre, double-blind, non-inferiority randomised controlled trial. Lancet 2018;392(10154):1197-1206. doi: 10.1016/S0140-6736(18)31723-9.
- Chang AB, Bush A, Grimwood K. Diagnosis and management of children with bronchiectasis. Lancet 2018 Sep 8;392(10150):866-879. doi: 10.1016/S0140-6736(18)31554-X
- Chalmers JD, Chang AB, Chotirmall SJ, Dhar R, McShane PJ. Bronchiectasis. Nature Rev Disease Primers 2018;4(1):45. doi: 10.1038/s41572-018-0042-3
- Chang AB, Grimwood K. Antibiotics for childhood pneumonia: do we really know how long to treat? N Engl J Med 2020; 383(1):77-79. doi: 10.1056/NEJMe2016328
- Chang AB, Zacharasiewicz A, Goyal V, Boyd J, Alexopoulou E, Aliberti S, Bell L, Bush A, Claydon A, Constant C, Fortescue R, Hill AT, Karadag B, Powell Z, Wilson C, Grimwood K, Kantar A; other members of Child-BEAR-Net. Task Force report: European Respiratory Society statement for defining respiratory exacerbations in children and adolescents with bronchiectasis for clinical trials. Eur Respir J. 2022 Nov 3;60(5):2200300 doi: 10.1183/13993003.00300-2022.
- Chang AB, Fortescue R, Grimwood K, Alexopoulou E, Bell L, Boyd J, Bush A, Chalmers JD, Hill AT, Karadag B, Midulla F, McCallum GB, Powell Z, Snijders D, Song WJ, Tonia T, Wilson C, Zacharasiewicz A, Kantar A. European Respiratory Society guidelines for the management of children and adolescents with bronchiectasis. Eur Respir J 2021: 58(2):2002990. doi: 10.1183/13993003.02990-2020
- de Benedictis FM, Kerem E, Chang AB, Colin AA, Zar HJ, Bush A. Complicated pneumonia in children. Lancet. 2020; 396(10253):786-798.
For more publications by Prof. Anne Chang visit: https://researchers.cdu.edu.au/en/persons/anne-chang/publications/
According to a Stanford University study, there were 22 academics from CDU and Menzies School of Health research who ranked in the top two per cent of researchers referenced in their respected disciplines for 2020.
A new $1.6 million Australian-UK world-first project aimed at preventing wheeze in preschool children and potentially asthma in later childhood by using an orally administered bacteria lysate to boost immune systems has been announced.
Congratulations to Professor Anne Chang FRACP who has been announced as the 2021 Howard Williams Medal winner.
Menzies School of Health Research Professor Bart Currie, Professor Anne Chang AM, Professor Ric Price, Associate Professor Steven Tong, Professor Nicholas Anstey, Professor Joshua Davis, Professor Alan Cass, Professor Peter Morris and Professor Amanda Leach
Media alert | Outcomes of protracted bacterial bronchitis in children: A 5‐year prospective cohort study
Findings from the first prospective longer-term outcome NHMRC-funded study for children with protracted bacterial bronchitis (PBB) in children have identified a link between children with PBB and asthma, highlighting the importance of identifying potentially treatable symptoms in children with chronic respiratory diseases.
Menzies senior research fellow Dr Michael Binks examined acute lower respiratory infection (ALRI) hospital admissions among Indigenous infants in the Northern Territory from 2006 to 2015, across three periods of different pneumococcal conjugate vaccine (PCV) use.
$6 million in research funding for three Indigenous health grants in the Northern Territory. This includes $2.5 million for an NHMRC Centre of Research Excellence at the Menzies School of Health Research to prevent and manage bronchiectasis, a lung disease which results in recurrent chest infections and is particularly common in Aboriginal and Torres Strait Islander people.
At a health centre in Melbourne for Aboriginal and Torres Strait Islanders in the late 1980s, medical student Anne Chang had her eyes opened to Indigenous disadvantage in Australia
Two Menzies School of Health Research clinician-researchers have secured competitive NHMRC funding to continue their valuable work over the coming years.
Indigenous Affairs Minister Nigel Scullion and Indigenous Health Minister Ken Wyatt AM today announced the National Health and Medical Research Council (NHMRC) funding for researchers at Darwin’s Menzies School of Medical Research, covering Indigenous-specific and broader health projects.
High-quality evidence informs chronic cough guidelines Results from the first multicentre randomised controlled trial on chronic cough in children led by our child health respiratory team were incorporated into the updated American College of Chest...
Three Menzies staff - Professor Anne Chang, Dr Gurmeet Singh and Dr Elizabeth McDonald - were involved in this study. The paper, published in the International Journal of Environmental Research and Public Health, linked preterm births with extreme heat.
Three Menzies researchers inducted as Fellows of the newly formed Australian Academy of Health and Medical Sciences.
Menzies' head of child health Professor Anne Chang was recently awarded a senior practitioner fellowship as part of the National Health and Medical Research Council's yearly multi-million dollar funding round.
One doctor’s mission to beat childhood lung disease.
Two esteemed lung health and cancer research programs from the Menzies School of Health Research were today declared ‘Centres for Research Excellence’ and awarded funding of $2.5 million each over five years.