PhD student; Timika WH&S and Equipment Officer
Bachelor of Science (Honours in Biochemistry), University of Western Australia, 2010; Bachelor of Science (Molecular Biology & Biotechnology), University of Western Australia, 2009;
The role of the human spleen and platelets in the pathology of malaria infection in Timika, Southern Papua, Indonesia
Steven grew up in Indonesia and came to Australia in 2007 to complete his undergraduate degree at the University of Western Australia in Perth.
In 2012, Steven relocated to Darwin and joined Menzies as a research assistant in the Global and Tropical Health team, focusing on malaria research.
In 2015, Steven continued his education by commencing a PhD course at Menzies. His current project explores the role of the human spleen and platelets in the pathology of malaria infection in Timika, Southern Papua, Indonesia
- Pathophysiological characterization of the spleen in human malaria infection in Southern Papua, Indonesia
- Role of platelets in the pathology of uncomplicated and severe malaria infection
- Characterization of Dendritic cells and regulatory T cells in sub-microscopic, asymptomatic and uncomplicated malaria infections
- Kho, S., Marfurt, J., Handayuni, I., Pava, Z., Noviyanti, R., Kusuma, A., et al. (2016). Characterization of blood dendritic and regulatory T cells in asymptomatic adults with sub-microscopic Plasmodium falciparum or plasmodium vivax infection. Malaria Journal, 15, 328.
- Wirjanata, G., Handayuni, I., Prayoga, P., Apriyanti, D., Chalfein, F., Sebayang, B.F., et al. (2015). Quantification of Plasmodium ex vivo drug susceptibility by flow cytometry. Malaria Journal ,14(1), 417.
- Kho, S., Marfurt, J., Noviyanti, R., Kusuma, A., Piera, K., Burdam, F.H., et al. (2015). Preserved dendritic cell HLA-DR expression and reduced regulatory T cell activation in asymptomatic plasmodium falciparum and P. vivax infection. Infection and Immunity, 83(8), 3224.
Could a new defence against malaria be found in human blood? Research suggests that human platelets ó a component of the blood ó form a first-line defence against the malaria parasite.
The study, which has just been published in the prestigious journal Blood, was led by Associate Professor Brendan McMorran at ANU and Professor Nick Anstey at Darwin's Menzies School of Health Research
The study, published by the Menzies School of Health Research (MSHR) in Australia's Northern Territory (NT), revealed that platelets attack and kill malaria parasites in the bloodstream.
The humble platelet is usually regarded as just a tiny cell that helps the blood clot. A study just published in the prestigious journal Blood has found that platelets attack and kill malaria parasites in infected humans to reduce the number of parasites circulating in their blood.