Associate Professor Matthew Grigg
Principal Research Fellow
Qualifications:
PhD, Charles Darwin University, 2017; Diploma of Tropical Medicine and Hygiene, Gorgas Memorial Institute, Peru, 2016; Bachelor of Medicine and Bachelor of Surgery, University of Melbourne, 2007; Bachelor of Medical Science, University of Melbourne, 2007.
Location:
Darwin - Royal Darwin Hospital; Sabah - Malaysia
Biography:
Matt is a NHMRC Emerging Leader II who has experience conducting and leading studies related to the epidemiology, diagnostics, and clinical drug trials of malaria and other tropical infectious diseases in Southeast Asia, with a focus on zoonotic malaria due to the monkey parasite Plasmodium knowlesi.
Matt also works as a clinician in Indigenous health in remote communities in East Arnhem Land.
Research Themes
- Parasite and human genetic risk factors for emerging Plasmodium knowlesi malaria
- ZOOMAL - Evaluating zoonotic malaria transmission and agricultural land use in Indonesia
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Grigg, M.J., William, T., Barber, B.E., Rajahram, G.S., Menon, J., Schimann, E., Piera, K.A., Wilkes, C.S., Patel, K., Chandna, A., Drakeley, C.J., Yeo, T.W., Anstey, N.M. (2018). Age-related clinical spectrum of Plasmodium knowlesi malaria and predictors of severity. Clinical Infectious Diseases. http://doi.10.1093/cid/ciy065. PMID: 29873683
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Grigg, M.J., William, T., Menon, J., Dhanaraj, P., Barber, B.E. & Wilkes, C.S. (2016). Artesunate–mefloquine versus chloroquine for treatment of uncomplicated Plasmodium knowlesi malaria in Malaysia (ACT KNOW): an open-label randomised controlled trial. The Lancet Infectious Diseases, 16(2), 180-188. http://doi.org/10.1016/S1473-3099(15)00415-6. PMID: 26603174
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Grigg, M.J., Cox, J., William, T., Jelip, J., Fornace, K.M., Brock, P.M., von Seidlein, L., Barber, B.E., Anstey, N.M., Yeo, T.W. & Drakeley, C.J. (2017). Individual factors associated with the risk of acquiring human Plasmodium knowlesi malaria in Malaysia: a case-control study. The Lancet Planetary Health, 1(3), e97-104. http://doi.org/S2542-5196(17)30031-1. PMID: 28758162
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Grigg, M.J., William, T., Barber, B.E., Rajahram, G.S., Menon, J., Schimann, E., Wilkes, C.S., Patel, K., Chandna, A., Price, R.N., Yeo, T.W. & Anstey, N.M. (2017). Artemether-lumefantrine versus chloroquine for the treatment of uncomplicated Plasmodium knowlesi malaria (CAN KNOW): an open-label randomized controlled trial. Clinical Infectious Diseases, 66(2), 229-232. http://doi.10.1093/cid/cix779. PMID: 29020373
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Grigg, M.J., William, T., Menon, J., Barber, B.E., Wilkes, C.S., Rajahram, G.S., Edstein, M.D., Auburn, S., Price, R.N., Yeo, T.W. & Anstey, N.M. (2016). Efficacy of artesunate-mefloquine against high-grade chloroquine-resistant Plasmodium vivax malaria in Malaysia: an open-label randomised controlled trial. Clinical Infectious Diseases, 62(11) 1403-11. http://doi.org/10.1093/cid/ciw121. PMID: 27107287
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Charon, J., Grigg, M.J., Eden, J.S., Piera, K.A., William, T., Rose, K., Davenport, M.P., Anstey, N.M. & Holmes, E.C. (2019). Matryoshka RNA virus 1: a novel RNA virus associated with Plasmodium parasites in human malaria. PloS Pathogens, 15(12). http://doi.10.1371/journal.ppat.1008216. PMID: 31887217
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Grigg, M.J. & Snounou, G. (2017). Plasmodium simium: a Brazilian focus of anthropozoonotic vivax malaria? The Lancet Global Health, 5(10), e961-962. http://doi.10.1016/S2214-109X(17)30343-1. PMID: 28867402
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Grigg, M.J., Barber, B.E., Marfurt, J., Imwong, M., William, T., Bird, E., Piera, K., Aziz, A., Boonyuen, U., Drakeley, C.J., Cox, J., White, N.J., Cheng, Q., Yeo, T.W., Auburn, S. & Anstey, N.M. (2016). Dihydrofolate-reductase mutations in Plasmodium knowlesi appear unrelated to selective drug pressure from putative human-to-human transmission in Sabah, Malaysia. PloS ONE, 11(3). http://doi.org/10.1371/journal.pone.0149519.t001. PMID: 26930493
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Piera, K.A., Aziz, A., William, T., Bell, D., González, I.J., Barber, B., Anstey, N.M. & Grigg, M.J. (2017). Detection of P. knowlesi, P. falciparum and P. vivax using loop-mediated isothermal amplification (LAMP) in a co-endemic area in Malaysia. Malaria Journal, 16(1), 29. http://doi.org/10.1186/s12936-016-1676-9. PMID: 28086789
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Grigg, M.J., William, T., Barber, B.E., Parameswaran, U., Bird, E., Piera, K., Aziz, A., Dhanaraj, P., Yeo, T.W. & Anstey, N.M. (2014). Combining parasite lactate dehydrogenase-based and histidine rich protein-2 rapid tests to improve specificity for the diagnosis of malaria due to Plasmodium knowlesi and other Plasmodium species in Sabah, Malaysia. Journal of Clinical Microbiology. http://doi.org/10.1128/JCM.00181-14. PMID: 24696029
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Medical Express | Using paracetamol for protecting kidneys in patients with severe malaria
Dr. Daniel Cooper said the findings are important because they will help provide the best possible treatment to patients with severe malaria.
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Using paracetamol for protecting kidneys in patients with severe malaria
Paracetamol is used in many illnesses for the relief of pain and fever, but a study just published in Clinical Infectious Diseases has shown that it may also help protect against kidney damage in patients with malaria.
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Combating zoonotic diseases in our region
The Australian research institutions receiving funding through the program include CSIRO, Menzies School of Health Research, University of Melbourne’s Nossal Institute for Global Health, Australian Centre for Disease Preparedness & the Burnet Institute.
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DFAT: Foreign policy in action - malaria research
Matthew Grigg is a senior research fellow at the Menzies School of Health Research and spent several years researching mosquitoes and malaria while living in a small town called Kudat in Sabah, Malaysia.
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Developing Northern Australia 2017 Implementation Report
Page 20 - Case Study | The Australian Government funded HOT NORTH project has hit the ground running in 2017, and is building north Australia’s expertise and capacity in tropical medicine through research projects that will transfer new knowledge to communities.
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Award no tall order for Matthew - Darwin Sun
A DARWIN scientist has been named the Young Tall Poppy Scientist of the Year in recognition of his research into a type of monkey malaria transmitted to humans via mosquitoes.
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Monkey malaria researcher presented with NT Young Tall Poppy award
Dr Matthew Grigg's research into monkey malaria has already changed WHO treatment guidelines and saved lives across Southeast Asia, writes Sarah Condie - Cosmos Magazine
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Katherine Times | Dr Grigg wins science award
Menzies School of Health Research clinical research fellow Dr Matthew Grigg has been named the 2017 NT Young Tall Poppy Scientist of the Year.
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Monkey malaria researcher named NT Young Tall Poppy
Menzies School of Health Research (Menzies) clinical research fellow Dr Matthew Grigg has been named the 2017 NT Young Tall Poppy Scientist of the Year in recognition for ongoing research into Plasmodium knowlesi (P. knowlesi) malaria, a type of monkey malaria transmitted to humans via mosquitos in Southeast Asia.
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Malaria parasite spreads from howler monkeys to humans
Matthew J Grigg, of the Menzies School of Health Research in Darwin, Australia and Georges Snounou, of the Sorbonne University in Paris, France, say it is imperative that studies establish whether this is the simium parasite or whether it might be a reservoir of vivax in Brazilian monkeys, which “would pose a substantial threat to malaria elimination throughout the continent and possibly beyond”
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Adult male farmers most at risk of contracting monkey malaria in Malaysia
Lead author, Menzies School of Health Research research fellow, Dr Matthew Grigg has specialised in identifying and researching risk factors and treatment for P. knowlesi malaria in Sabah, Malaysian Borneo.
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HOT NORTH Fellowships to improve health outcomes in the tropics
Five post-doctoral health professionals have been awarded Fellowships to help close critical gaps in health outcomes in northern Australia and the Asia-Pacific region as part of the unique collaborative program Improving Health Outcomes in the Tropical North (HOT NORTH), led by the Darwin-based Menzies School of Health Research (Menzies).