Program aims:
Multidrug-resistant (MDR) tuberculosis and multidrug-resistant (MDR) malaria pose major public health challenges, threatening health security across the Asia-Pacific region. Our team has a proven 20-year record of strengthening research collaboration in Southeast Asia and Papua New Guinea and in facilitating implementation of research findings into policy and practice. We will work with partners from our regional networks to increase the research capacity and expertise of our partners, developing and testing health systems strategies to prevent and contain multidrug-resistant malaria and TB, and strengthening the capacity of health systems.
This will expand our system strengthening activities, and regional collaborations established with the Tropical Disease Research Regional Collaboration Initiative (TDRRCI). We will build upon our existing capacity development, to scale up new health interventions that address health security and achieve policy transfer, driven by systems-oriented implementation research
- improving service delivery for the prevention and treatment of infection
- implementing new approaches to tuberculosis case detection and prevention, particularly multi-drug resistant strains
- molecular surveillance for monitoring the emergence and spread of MDR organisms at sentinel sites, so that healthcare resources can be prioritised for high risk populations
- The team will support and upskill local researchers to address both diseases
Chief Investigator:
Co-investigators
- Professor Stephen Graham - University of Melbourne
- Professor Anna Ralph - Menzies School of Health Research
- Doctor Jeanne Poespoprodjo - Gadjah Mada University, Yogyakarta, Indonesia
- Doctor Evelyn Lavu - National Department of Health Papua New Guinea
- Doctor Philipp DuCros - Burnet Institute
- Professor Nicholas Anstey - Menzies School of Health Research
- Doctor Christopher Morgan - Burnet Institute
- Doctor Suman Majumdar - Burnet Institute
- Doctor Rintis Noviyanti – Eijkman Institute of Molecular Biology, Indonesia
Associate Investigators
- Doctor Sarah Auburn- Menzies School of Health Research
- Doctor Geoff Chan - Burnet Institute
- Associate Professor Christopher Coulter - Queensland Mycobacterium Reference Laboratory
- Doctor Paison Dakulala - National Department of Health, Papua New Guinea
- Angela Devine – University of Oxford, UK
- Associate Professor Freya Fowkes - University of Melbourne, Monash University
- Doctor Enny Kenangalem - Papuan Community Health and Development Foundation, Indonesia
- Doctor Trisasi Lestari - Gadjah Mada University, Indonesia
- Professor Koen Peeters - Institute of Tropical Medicine, Belgium
- Doctor Leanne Robinson – Burnet Institute
Program Manager:
Program Dates:
- July 2018 - June 2021
Funders:
Collaborators:
- Burnet Institute
- University of Melbourne
- Gadjah Mada University, Indonesia
- National Department of Health, Papua New Guinea
- Central Public Health Lab, PNG
- Western Province Health Office, PNG
- Papuan Health and Community Development Foundation
- Eijkman Institute of Molecular Biology, Jakarta
- Institute of Tropical Medicine Antwerp
- Wellcome Trust Sanger Institute
- Asia Pacific Malaria Elimination Network
- WorldWide Antimalarial Resistance Network
Australian partners
Menzies School of Health Research | Darwin |
Lead organisation; Medical research institute |
Burnet Institute | Melbourne | Consortium partner; Medical research institute; International development organisation |
Queensland Mycobacterium Reference Laboratory (QMRL) | Brisbane | Supranational reference laboratory for TB including for PNG providing capacity development in WGS |
International partners:
Papuan Health and Community Development Foundation | Non-Government Organisation | Papua, Indonesia | Delivery of field activities for TB and malaria systems strengthening in Papua |
Rumah Sakit Mitra Masyarakat | Health services | Papua, Indonesia | Will participate in the adherence interventions and surveillance of impact |
Mimika District Health Authority | Government | Papua, Indonesia | The DHO will work in community health systems strengthening in Papua |
Eijkman Institute of Molecular Biology | Research institute | Jakarta, Indonesia | Undertake the molecular analysis of TB and malaria in Indonesia |
Gadjah Mada University | University | Yogyakarta, Indonesia | The university provides supervision and training for TB activities in eastern Indonesia |
National Department of Health | Government | Papua New Guinea | Stewardship of MDR-TB response in PNG providing knowledge dissemination and policy translation |
Western Province Health Office | Government | Papua New Guinea | Stewardship of Daru TB program, capacity building, community engagement and systems strengthening |
Central Public Health Laboratory | Government | Papua New Guinea | Provide laboratory diagnostics, national surveillance for TB and collaborate with QMRL |
Institute of Tropical Medicine in Antwerp | University | Antwerp, Belgium | Medical Anthropology Unit (Al Peeters) will help to design, implement and analyse the mixed methods in Papua |
Wellcome Trust Sanger Institute | Research institute | Cambridge, United Kingdom | Design and analysis of amplicon sequencing of P.falciparium and P.vivax |
Asia Pacific Malaria Elimination Network | Non-Government Organisation | Singapore | Wider community engagement and dissemination of malarial activities |
WorldWide Antimalarial Resistance Network | University | Oxford, United Kingdom | Geospatial mapping / online presentation of molecular markers of antimalarial drug resistance |