One in five Indigenous infants are hospitalised with acute lower respiratory infections (ALRI) in their first year of life. Recent international studies suggest an association between vitamin D deficiency and ALRI despite adequate sun exposure. This study was the first to characterise vitamin D levels in Indigenous children and investigated the association between vitamin D deficiency and ALRI in this population.
To describe vitamin D among Indigenous mothers and infants in the Northern Territory (NT) and determine whether cord blood vitamin D is associated with the risk of infant ALRI hospitalisation.
In a cohort of Indigenous mother-infant pairs we measured vitamin D in maternal blood during pregnancy and at birth, in cord bloods and in infant blood at age 7 months. Cord blood vitamin D was the primary exposure. The primary outcome measure was ALRI hospitalisations during the first 12 months of infancy, identified using International Classification of Diseases coding.
Our research has found:
Cord blood vitamin D concentrations were approximately half that of maternal blood in the third trimester of pregnancy (~7 weeks earlier). Most (80%) cord bloods were vitamin D insufficient (<75 nmol/L) by existing guidelines and were lower among infants who were subsequently hospitalised with an ALRI.
Implications for policy and practice:
These results could inform maternal and/or infant vitamin D supplementation programs for the prevention of infant ALRI.
Randomised controlled trials to determine the efficacy of vitamin D supplementation during pregnancy or infancy against infant ALRI’s.
- Channel 7 – Children’s Research Foundation
- National Health and Medical Research Council post-graduate scholarship and Douglas and Lola Douglas scholarship in Medical Science - awarded to Michael Binks.
- Binks M.J., Smith-Vaughan H.C., Bar-Zeev N., Chang A.B. & Andrews R.M. (2014). Vitamin D insufficiency among hospitalised children in the Northern Territory. Journal of Paediatrics and Child Health, 50(7), 512-8.
- Binks M.J., Smith-Vaughan H.C., Marsh R.M., Chang A.B. & Andrews R.M. Cord blood vitamin D status and the risk of acute lower respiratory infection for Indigenous infants in the Northern Territory of Australia during their first year of life. Manuscript in preparation.