The aim of the Closing the loop on life-threatening melioidosis infections: observational research informing clinical practice change and policy for adults with severe kidney disease study is to determine the efficacy and safety of prophylaxis with daily oral TMP/SXT for melioidosis in haemodialysis patients from the Top End during the wet season from November 2014 to April 2015.
Territorians who need dialysis to manage severe kidney disease were among a very high risk group susceptible for melioidosis infections and related harms. In response to this, we undertook this study.
Implications for policy and practice:
This practice has been successfully embedded in standard care in the Top-End of the Northern Territory.
Our research has found:
Melioidosis risk can be significantly minimized in this high risk group through a comprehensive strategy providing useful and meaningful information to clients and dialysis health care staff, along with the antibiotic prevention treatment.
- Jaqui Hughes
- William Majoni (Royal Darwin Hospital)
- Bart Currie
- Bianca Heron (Royal Darwin Hospital)
- Chalmers RM, Majoni SW, Ward L, Perry GJ, Jabbar Z, Currie BJ. Melioidosis and end-stage renal disease in tropical northern Australia. Kidney Int. 2014;86(5):867-70.
- Jabbar Z, Currie BJ. Melioidosis and the kidney. Nephrology (Carlton, Vic). 2013;18(3):169-75.
- Majoni SW, Heron B, Hughes JT, Currie BJ. Trimethoprim/sulfamethoxazole (TMP/SXT) prophylaxis to reduce rates of meliodosis in high risk haemodialysis patients in the Top End of Australia. Nephrology. 2016;21(S2):118.
- The 2016 Harry Christian Giese Research into Action Award.
More people are being infected by a potentially fatal bacterium in the Northern Territory, and health experts suspect building works could have something to do with the rise in cases.
In the new work, Mirjam Kaestli of Charles Darwin University, Australia and colleagues including Menzies School of Health Research sampled water and biofilms from three remote Indigenous communities in Australia’s Northern Territory.
CDU Research Fellow Mirjam Kaestli and colleagues including Menzies School of Health Research sampled water and biofilms from three remote Indigenous communities in the Northern Territory.
Melioidosis is killing Territory crocodiles, according to a paper written by researchers at the Menzies School of Health Research.
A ground-breaking study by a north Australian research team which identified a deadly bacterium responsible for killing saltwater crocodiles at a Top End Wildlife Park has recently been published in the journal, Microbial Genomics.
A deadly tropical disease that affects humans was responsible for killing two crocodiles near Darwin, flipping previously held beliefs the predators were highly resistant to infection.
The research, from Menzies School of Health Research was published in the Microbial Genomics journal.
Menée par Menzies, la recherche sur la santé (Menzies), l'étude a porté sur la mort de deux crocodiles d'eau salée éclos dans le parc animalier à l'aide du séquençage à haute résolution du génome entier et de la phylogénétique comparative.
Dr Audrey Rachlin focused on the environmental bacterium Burkholderia pseudomallei, which causes melioidosis.