Aim:

The aim of the Closing the loop on life-threatening melioidosis infections: observational research informing clinical practice change and policy for adults with severe kidney disease study is to determine the efficacy and safety of prophylaxis with daily oral TMP/SXT for melioidosis in haemodialysis patients from the Top End during the wet season from November 2014 to April 2015.

Summary:

Territorians who need dialysis to manage severe kidney disease were among a very high risk group susceptible for melioidosis infections and related harms[1].  In response to this, we undertook this study. 

Implications for policy and practice:

This practice has been successfully embedded in standard care in the Top-End of the Northern Territory.

Our research has found:

Melioidosis risk can be significantly minimized in this high risk group through a comprehensive strategy providing useful and meaningful information to clients and dialysis health care staff, along with the antibiotic prevention treatment.

Chief investigators:
Start date:

September 2014

 

[1]

  • Chalmers RM, Majoni SW, Ward L, Perry GJ, Jabbar Z, Currie BJ. Melioidosis and end-stage renal disease in tropical northern Australia. Kidney Int. 2014;86(5):867-70.
  • Jabbar Z, Currie BJ. Melioidosis and the kidney. Nephrology (Carlton, Vic). 2013;18(3):169-75.

 

  1. Majoni SW, Heron B, Hughes JT, Currie BJ. Trimethoprim/sulfamethoxazole (TMP/SXT) prophylaxis to reduce rates of meliodosis in high risk haemodialysis patients in the Top End of Australia. Nephrology. 2016;21(S2):118. 
     

 

Funders:
  • The 2016 Harry Christian Giese Research into Action Award.
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