- To determine the best pneumococcal conjugate vaccine schedule for Indigenous children and others at high risk of invasive and mucosal respiratory infection throughout the first three years of life
- To compare type-specific immune correlates of protection, bacterial carriage and clinical outcomes at 18 and 36 months of age following randomisation to different combinations of primary and booster vaccines.
- To determine whether a mixed schedule of PHiD-CV10 and PCV13 can be used to provide broader immune protection against carriage and infection due to all vaccine components in the second and third years of life.
- To determine whether PHiD-CV10 is immunogenic and effective in reducing NTHi carriage in Indigenous children at high risk of NTHi ear and chest infection.
- Professor Amanda Leach, Menzies School of Health Research
- Professor Edward Mulholland, Menzies School of Health Research
- Professor Mathuram Santosham
- Professor Paul Torzillo, Royal Prince Alfred Hospital, Camperdown NSW
- Professor Ngiare Brown, University of Wollongong
- Professor Peter McIntyre, University of Sydney
- Associate Professor Heidi Smith-Vaughan, Menzies School of Health Research
- Ms Anne Balloch, Murdoch Childrens Research Institute
- Mr Mark Chatfield, Menzies School of Health Research.