• To determine the best pneumococcal conjugate vaccine schedule for Indigenous children and others at high risk of invasive and mucosal respiratory infection throughout the first three years of life
  • To compare type-specific immune correlates of protection, bacterial carriage and clinical outcomes at 18 and 36 months of age following randomisation to different combinations of primary and booster vaccines.
  1. To determine whether a mixed schedule of PHiD-CV10 and PCV13 can be used to provide broader immune protection against carriage and infection due to all vaccine components in  the second and third years of life.
  2. To determine whether PHiD-CV10 is immunogenic and effective in reducing NTHi carriage in Indigenous children at high risk of NTHi ear and chest infection.
Chief investigators:
  • Professor Amanda Leach, Menzies School of Health Research
  • Professor Edward Mulholland, Menzies School of Health Research
  • Professor Mathuram Santosham
  • Professor Paul Torzillo, Royal Prince Alfred Hospital, Camperdown NSW
  • Professor Ngiare Brown, University of Wollongong
  • Professor Peter McIntyre, University of Sydney
  • Associate Professor Heidi Smith-Vaughan, Menzies School of Health Research
  • Ms Anne Balloch, Murdoch Childrens Research Institute
  • Mr Mark Chatfield, Menzies School of Health Research.