Linking genomics of Burkholderia pseudomallei to melioidosis: diversity of clini

Summary:

We will use whole genome sequencing of a large number of Burkholderia pseudomallei  isolates to further elucidate correlates with clinical and epidemiological features of melioidosis. We are uniquely placed to do this work because we will have bacterial isolates and comprehensive clinical data from more than 750 sequential patients in the 25 year Darwin Prospective Melioidosis Study.      

Chief investigators:

• Professor Bart Currie
• Professor Paul Keim
• Associate Professor Apichai Tuanyok
• Mark Mayo
• Dr Mirjam Kaestli
• Dr Erin Price
• Dr Derek Sarovich

Project manager:

• Mark Mayo

Contact information:

• Mark Mayo

Project dates:

The study commenced in January 2013 and is scheduled for completion in December 2015.

Funder:

• National Health and Medical Research Council (NHMRC)

1. Price, E.P., Sarovich, D.S., Mayo, M., Tuanyok, A., Drees, K.P., Kaestli, M. et al. (2013). Within-Host Evolution of Burkholderia pseudomallei over a Twelve-Year Chronic Carriage Infection. Mbio 4(4).
2. Sarovich, D.S., Ward, L., Price,E.P., Mayo,M., Pitman, M. C., Baird,R.W. et al. (2014). Recurrent Melioidosis in the Darwin Prospective Melioidosis Study: Improving Therapies Mean that Relapse Cases Are Now Rare. Journal of Clinical Microbiology, 52(2), 650-653.