Aims:

Primary aim:

  • To determine if vitamin D insufficiency in cord blood is associated with a higher risk of hospitalisation for acute lower respiratory infection (ALRI) during the first year of life.

Secondary aims:

  • To examine the association between vitamin D insufficiency in cord blood and pathogen density in the nasopharynx at one month of age
  • To examine the association between vitamin D insufficiency in cord blood and the infant response to childhood pneumococcal conjugate vaccination (PCV) assessed at seven months of age
  • To examine:
  1. the association between maternal and infant serum vitamin D levels at birth
  2. the influence of vitamin D levels in breast milk on vitamin D levels in infant serum at seven months post partum.
Objectives:
  • To develop prevention strategies for ALRI involving vitamin D supplementation.
Summary:

One in five Indigenous infants are hospitalised with ALRI in their first year of life. Recent international studies suggest an association between vitamin D deficiency and ALRI despite adequate sun exposure. This study will be the first to characterise vitamin D levels in Indigenous children and will investigate the association between vitamin D deficiency and ALRI in this population.

Implications for policy and practice:

The results of this work could have implications for prevention strategies involving vitamin D supplementation for ALRIs.

Chief Investigators:
Contact information:
Project dates:

The project is scheduled to run from 2011 - 2014.

Funders:
  • Channel 7 – Children’s Research Foundation
  • National Health and Medical Research Council post-graduate scholarship and Douglas and Lola Douglas scholarship in Medical Science - awarded to Michael Binks.