- To determine if vitamin D insufficiency in cord blood is associated with a higher risk of hospitalisation for acute lower respiratory infection (ALRI) during the first year of life.
- To examine the association between vitamin D insufficiency in cord blood and pathogen density in the nasopharynx at one month of age
- To examine the association between vitamin D insufficiency in cord blood and the infant response to childhood pneumococcal conjugate vaccination (PCV) assessed at seven months of age
- To examine:
- the association between maternal and infant serum vitamin D levels at birth
- the influence of vitamin D levels in breast milk on vitamin D levels in infant serum at seven months post partum.
- To develop prevention strategies for ALRI involving vitamin D supplementation.
One in five Indigenous infants are hospitalised with ALRI in their first year of life. Recent international studies suggest an association between vitamin D deficiency and ALRI despite adequate sun exposure. This study will be the first to characterise vitamin D levels in Indigenous children and will investigate the association between vitamin D deficiency and ALRI in this population.
Implications for policy and practice:
The results of this work could have implications for prevention strategies involving vitamin D supplementation for ALRIs.
The project is scheduled to run from 2011 - 2014.
- Channel 7 – Children’s Research Foundation
- National Health and Medical Research Council post-graduate scholarship and Douglas and Lola Douglas scholarship in Medical Science - awarded to Michael Binks.